HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 195
+	Hs
		1041151 CUL1_HUMAN (6-745): 0: 775: 36.24		NLRP3_HUMAN (1-184): 4.06e-53: 183: 15.79
+	Hs
		1043169 CUL4A_HUMAN (4-745): 0: 773: 26.86		NLRP3_HUMAN (1-184): 4.06e-53: 183: 15.79
+	Hs
		1043523 CUL4B_HUMAN (4-745): 0: 771: 27.79		NLRP3_HUMAN (1-184): 4.06e-53: 183: 15.79
+	Hs
		1042319 CUL3_HUMAN (1-745): 0: 768: 26.38		NLRP3_HUMAN (1-184): 4.06e-53: 183: 15.79
+	Hs
		1043203 CUL4A_HUMAN (4-745): 0: 773: 26.86		NLRP1_HUMAN (2-187): 1.31e-10: 61.7: 20.32
+	Hs
		1043563 CUL4B_HUMAN (4-745): 0: 771: 27.79		NLRP1_HUMAN (2-187): 1.31e-10: 61.7: 20.32
+	Hs
		1042479 CUL3_HUMAN (1-745): 0: 768: 26.38		NLRP1_HUMAN (2-187): 1.31e-10: 61.7: 20.32