HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31248990
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box, HMG_box~HMG_box_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006302 - double-strand break repair
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 215
+	Hs
		318429 NSD2_HUMAN (1-1365): 0: 988: 100.00		TOX4_HUMAN (91-163): 1.2e-27: 111: 38.36
+	Hs
		833583 NSD3_HUMAN (116-1340): 0: 764: 45.27		SOX3_HUMAN (5-84): 5.74e-25: 102: 23.75
+	Hs
		687244 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		HMGB2_HUMAN (1-187): 7.94e-42: 142: 82.89
+	Hs
		1065217 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		SSRP1_HUMAN (53-164): 1.6e-28: 114: 37.50
+	Mm
		1231056 Q6AXH7_MOUSE (904-1188): 1.19e-58: 218: 22.48		TOX4_MOUSE (91-163): 9e-28: 111: 38.36
+	Hs
		1065410 SETD2_HUMAN (852-1238): 1.68e-54: 212: 27.74		SSRP1_HUMAN (53-164): 1.6e-28: 114: 37.50
+	Hs
		872755 EHMT1_HUMAN (906-1224): 5.89e-56: 215: 21.43		SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91
+	Hs
		872638 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91
+	Hs
		872718 SETD2_HUMAN (852-1238): 1.68e-54: 212: 27.74		SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91
+	Hs
		1396306 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		SOX17_HUMAN (7-90): 3.94e-22: 94.8: 19.05
+	Hs
		1155797 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		HM20A_HUMAN (64-204): 9.18e-16: 76.3: 25.69
+	Hs
		1041500 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		SSRP1_HUMAN (53-164): 1.6e-28: 114: 37.50
+	Hs
		1401396 EHMT1_HUMAN (906-1224): 5.89e-56: 215: 21.43		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Hs
		1396284 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Hs
		1401379 SETD2_HUMAN (852-1238): 1.68e-54: 212: 27.74		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Hs
		604673 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		UBF1_HUMAN (10-158): 4.17e-09: 57.8: 23.60
+	Hs
		872231 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91
+	Hs
		1024142 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		TFAM_HUMAN (95-186): 2.96e-09: 57.1: 17.39
+	Hs
		872641 NSD1_HUMAN (69-658): 8.18e-26: 118: 14.33		SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91
+	Hs
		161431 KMT2D_HUMAN (1239-1363): 7.22e-10: 66.3: 20.28		SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91