HitPredict

Interactor 1: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17353931, 14743216
Identification Methods	anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 716 Hs			1 456
+	Hs
		1355364 TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1050301 IKKE_HUMAN (1-716): 1.32e-170: 508: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1355363 TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Dm
		1365058 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		RUVB1_DROME (1-455): 0: 660: 79.56
+	Dm
		1358864 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		RUVB2_DROME (5-455): 0: 640: 45.25