HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: KLDC2 (Q9Y2U9)
Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)
Gene: KLHDC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 0.60 0.732

The method score is based on:

Property Details
Experiments 28514442, 33961781, 36805027, 18187417, 21145461, unassigned3799
Identification Methods affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0016567 - protein ubiquitination
GO:0031462 - Cul2-RING ubiquitin ligase complex
GO:0140627 - ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 745
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Service provided by Combinatics, Japan

Last updated: 11Aug2025