HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLH11 (Q9NVR0)
Kelch-like protein 11
Gene: KLHL11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	28514442, 33130828, 33961781, 35563538, 37495603, 21145461, 37156295, 23349464
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, x-ray crystallography, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 708
+	Hs
		1113077 CUL3_HUMAN (1-768): 0: 943: 100.00		KEAP1_HUMAN (8-663): 8.72e-154: 461: 17.95
+	Hs
		329059 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL2_HUMAN (36-663): 1.68e-142: 431: 21.59
+	Hs
		1113267 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH12_HUMAN (437-706): 2.64e-54: 197: 13.92
+	Hs
		1114525 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH13_HUMAN (454-707): 2.82e-45: 173: 14.62
+	Hs
		1113682 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH36_HUMAN (453-705): 1.91e-41: 162: 15.71
+	Hs
		1113634 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL7_HUMAN (85-541): 1.89e-41: 161: 23.80
+	Hs
		1113453 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH17_HUMAN (463-707): 9.1e-39: 154: 8.98
+	Hs
		161296 CUL3_HUMAN (1-768): 0: 943: 100.00		ENC1_HUMAN (71-481): 4.05e-38: 152: 25.58
+	Hs
		1114518 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL8_HUMAN (486-706): 1.65e-37: 150: 12.67
+	Hs
		1114259 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH25_HUMAN (71-534): 5.12e-35: 142: 25.63
+	Hs
		1113681 CUL3_HUMAN (1-768): 0: 943: 100.00		Q8N4I8_HUMAN (85-331): 7.46e-36: 139: 31.17
+	Hs
		1114054 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL5_HUMAN (556-707): 4.49e-31: 131: 9.87
+	Hs
		1114459 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH28_HUMAN (535-706): 4.36e-30: 127: 11.60
+	Hs
		1114520 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL9_HUMAN (557-706): 8.34e-26: 114: 10.00
+	Hs
		1113399 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH10_HUMAN (558-706): 8.65e-25: 111: 15.33
+	Hs
		320822 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH18_HUMAN (338-496): 8.5e-24: 108: 23.13
+	Hs
		1113454 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH24_HUMAN (522-708): 4.88e-23: 106: 11.05
+	Hs
		1114400 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL1_HUMAN (609-707): 1.38e-17: 89.2: 9.09
+	Hs
		1114239 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL4_HUMAN (609-707): 7.96e-17: 86.9: 8.08
+	Hs
		1113862 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL6_HUMAN (602-705): 2.43e-16: 85: 12.50