HitPredict

Interactor 1: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.715

Property	Details
Experiments	21822214
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 456 Hs			1 639
+	Hs
		1261029 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Mm
		1246941 BLNK_MOUSE (1-456): 8.2e-75: 243: 85.56		SH3K1_MOUSE (1-638): 2.12e-83: 278: 30.09
+	Hs
		655439 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		209129 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Mm
		292689 BLNK_MOUSE (1-456): 8.2e-75: 243: 85.56		GRAP2_MOUSE (2-328): 2.38e-46: 168: 15.27
+	Hs
		275217 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		924727 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		222321 O54737_MOUSE (1-444): 3.19e-60: 206: 58.22		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		209043 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		557750 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		129269 P85B_HUMAN (129-453): 1.23e-44: 168: 17.05		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		643091 P85A_MOUSE (121-453): 4.26e-43: 163: 14.41		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		655306 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		275193 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		924670 CLNK_HUMAN (73-443): 8.86e-38: 144: 21.35		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924534 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		557615 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		655386 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		557674 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Ce
		110116 TENSH_CAEEL (7-436): 5.69e-38: 149: 13.32		Q9U2T9_CAEEL (27-492): 3.56e-11: 68.5: 13.89