Protein: LCP2
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)

Gene: LCP2
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q13094

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005911 - cell-cell junction
GO:0006955 - immune response
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0035556 - intracellular signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

275193

GRAP2
GRB2-related adapter protein 2

20

20

Small-scale

0.991

High

924534

GRB2
Growth factor receptor-bound protein 2

16

20

Small-scale

0.985

High

167754

FYB1
FYN-binding protein 1

9

7

Small-scale

0.968

High

557674

NCK1
SH2/SH3 adapter protein NCK1

8

20

Small-scale

0.967

High

996556

ITK
Tyrosine-protein kinase ITK/TSK

6

20

Small-scale

0.938

High

548696

VAV
Proto-oncogene vav

6

16

Small-scale

0.936

High

580995

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

5

5

Small-scale

0.936

High

209043

NCK2
Cytoplasmic protein NCK2

4

20

High-throughput

0.914

High

277055

STAM2
Signal transducing adapter molecule 2

4

16

Small-scale

0.905

High

655347

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

6

Small-scale

0.863

High

665879

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

2

Small-scale

0.812

High

796468

ZAP70
Tyrosine-protein kinase ZAP-70

2

20

Small-scale

0.778

High

338356

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.775

High

796558

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.768

High

411700

LCK
Tyrosine-protein kinase Lck

2

20

Small-scale

0.737

High

433736

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.724

High

1024133

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.724

High

844037

FXR2
RNA-binding protein FXR2

5

1

High-throughput

0.718

High

610381

CBL
E3 ubiquitin-protein ligase CBL

4

6

Small-scale

0.683

High

666094

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.665

High

1024146

SH3G2
Endophilin-A1

1

20

High-throughput

0.656

High

383773

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

601909

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

1024132

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1024144

STAM1
Signal transducing adapter molecule 1

1

15

Small-scale

0.647

High

1024136

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.621

High

412165

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

442821

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

522951

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

992571

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

994845

GOGA2
Golgin subfamily A member 2

3

1

High-throughput

0.616

High

1024149

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

Small-scale

0.614

High

926990

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.576

High

981050

KPCT
Protein kinase C theta type

1

1

Small-scale

0.575

High

207444

LAT
Linker for activation of T-cells family member 1

2

1

Small-scale

0.571

High

1024138

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

5

Small-scale

0.569

High

1024142

LNX1
E3 ubiquitin-protein ligase LNX

2

4

High-throughput

0.553

High

409061

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.515

High

394635

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

909504

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.501

High

359902

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.481

High

790668

WASP
Actin nucleation-promoting factor WAS

1

6

Small-scale

0.479

High

919619

RAP1A
Ras-related protein Rap-1A

1

8

Small-scale

0.479

High

1024135

AB1IP
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

1

6

Small-scale

0.479

High

1024137

SKAP1
Src kinase-associated phosphoprotein 1

1

14

Small-scale

0.479

High

1024140

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1024145

PRAM
PML-RARA-regulated adapter molecule 1

1

4

Small-scale

0.479

High

931125

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.460

High

1024139

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1024141

PJA1
E3 ubiquitin-protein ligase Praja-1

1

2

Small-scale

0.457

High

1024147

WNK1
Serine/threonine-protein kinase WNK1

1

6

High-throughput

0.457

High

672660

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.457

High

1024150

ICOS
Inducible T-cell costimulator

1

0

Small-scale

0.426

High

519333

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

4

Small-scale

0.408

High

1024131

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.407

High

1024148

ELOV6
Very long chain fatty acid elongase 6

2

0

High-throughput

0.316

High

396927

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.269

Low

1024134

TRAT1
T-cell receptor-associated transmembrane adapter 1

1

0

Small-scale

0.261

Low

1024143

HAVR2
Hepatitis A virus cellular receptor 2

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024