HitPredict

Interactor 1: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27173435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 923 Hs			1 676
+	Hs
		1234852 KSR1_HUMAN (1-923): 0: 776: 100.00		PKHA7_HUMAN (6-454): 6.89e-45: 174: 13.48
+	Hs
		932066 EPHA4_HUMAN (185-912): 6.83e-165: 509: 14.60		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		710827 EPHB2_HUMAN (203-895): 5.41e-160: 498: 13.69		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		931845 EPHA5_HUMAN (185-888): 2.93e-156: 488: 13.82		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		710225 EPHA2_HUMAN (223-917): 4.46e-146: 459: 14.40		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		1286515 KSR1_HUMAN (1-923): 0: 776: 100.00		PHLB2_HUMAN (9-113): 1.51e-22: 105: 28.30
+	Hs
		440063 LCK_HUMAN (591-890): 2.25e-99: 322: 24.59		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		932137 EPHA4_HUMAN (185-912): 6.83e-165: 509: 14.60		PKHA1_HUMAN (7-205): 1.02e-32: 132: 19.80
+	Hs
		710581 EPHA2_HUMAN (223-917): 4.46e-146: 459: 14.40		PKHA6_HUMAN (6-512): 3.14e-45: 176: 14.26
+	Hs
		710305 EPHA2_HUMAN (223-917): 4.46e-146: 459: 14.40		PKHA7_HUMAN (6-454): 6.89e-45: 174: 13.48
+	Hs
		710500 EPHA2_HUMAN (223-917): 4.46e-146: 459: 14.40		PKHA2_HUMAN (2-229): 1.11e-46: 173: 21.55
+	Hs
		710895 EPHB2_HUMAN (203-895): 5.41e-160: 498: 13.69		PKHA1_HUMAN (7-205): 1.02e-32: 132: 19.80
+	Hs
		1147437 EPHA7_HUMAN (206-890): 1.2e-156: 488: 14.44		PKHA1_HUMAN (7-205): 1.02e-32: 132: 19.80
+	Hs
		640336 EPHA1_HUMAN (223-917): 1.86e-140: 444: 15.72		PKHA6_HUMAN (6-512): 3.14e-45: 176: 14.26
+	Hs
		931901 EPHA5_HUMAN (185-888): 2.93e-156: 488: 13.82		PKHA1_HUMAN (7-205): 1.02e-32: 132: 19.80
+	Hs
		401215 RAF1_HUMAN (229-908): 1.95e-144: 444: 22.18		CNKR2_HUMAN (5-376): 1.04e-38: 156: 16.89
+	Hs
		710337 EPHA2_HUMAN (223-917): 4.46e-146: 459: 14.40		PHLB2_HUMAN (9-113): 1.51e-22: 105: 28.30
+	Hs
		710307 EPHA2_HUMAN (223-917): 4.46e-146: 459: 14.40		PHLB3_HUMAN (9-121): 3.86e-18: 90.5: 28.07
+	Hs
		710339 EPHA2_HUMAN (223-917): 4.46e-146: 459: 14.40		PHLB1_HUMAN (8-113): 2.48e-16: 85.5: 26.27
+	Hs
		215893 LCK_HUMAN (591-890): 2.25e-99: 322: 24.59		SYNJ1_HUMAN (219-635): 5.66e-13: 74.8: 11.91