HitPredict

Interactor 1: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Interactor 2: DOCK5 (Q9H7D0)
Dedicator of cytokinesis protein 5
Gene: DOCK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras, DOCK_N~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Hs			1 1870
+	Hs
		581295 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOCK5_HUMAN (1-1870): 0: 1987: 100.00
+	Hs
		581043 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOCK1_HUMAN (1-1714): 0: 1911: 67.23
+	Hs
		1015434 RHOG_HUMAN (3-170): 1.69e-74: 238: 27.47		DOCK1_HUMAN (1-1714): 0: 1911: 67.23
+	Hs
		581206 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOCK2_HUMAN (1-1825): 0: 1844: 54.91
+	Dm
		828004 RAC1_DROME (3-180): 6.92e-80: 252: 25.52		Q8MQW7_DROME (683-1821): 0: 1050: 36.60
+	Hs
		581269 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOCK9_HUMAN (945-1640): 0: 705: 16.39
+	Hs
		953651 RAC3_HUMAN (3-168): 9.64e-79: 249: 27.22		DOCK9_HUMAN (945-1640): 0: 705: 16.39
+	Mm
		107030 CDC42_MOUSE (3-172): 5.7e-77: 244: 25.54		F8VPN7_MOUSE (945-1679): 0: 706: 15.77
+	Hs
		955556 CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54		DOCK9_HUMAN (945-1640): 0: 705: 16.39
+	Hs
		1145093 RAB35_HUMAN (5-168): 3.57e-76: 242: 24.70		DOCK9_HUMAN (945-1640): 0: 705: 16.39
+	Hs
		1015748 RHOG_HUMAN (3-170): 1.69e-74: 238: 27.47		DOCK9_HUMAN (945-1640): 0: 705: 16.39
+	Hs
		581092 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOC11_HUMAN (945-1650): 0: 656: 15.01
+	Mm
		59255 CDC42_MOUSE (3-172): 5.7e-77: 244: 25.54		DOC11_MOUSE (945-1650): 0: 662: 15.01
+	Hs
		953486 RAC3_HUMAN (3-168): 9.64e-79: 249: 27.22		DOC11_HUMAN (945-1650): 0: 656: 15.01
+	Hs
		955260 CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54		DOC11_HUMAN (945-1650): 0: 656: 15.01
+	Hs
		955461 CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54		DOC10_HUMAN (968-1676): 0: 641: 15.58
+	Mm
		953810 CDC42_MOUSE (3-172): 5.7e-77: 244: 25.54		DOC10_MOUSE (968-1677): 0: 634: 15.43
+	Hs
		955485 CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54		DOCK7_HUMAN (59-927): 3.61e-156: 532: 14.05
+	Hs
		1145061 RAB35_HUMAN (5-168): 3.57e-76: 242: 24.70		DOCK7_HUMAN (59-927): 3.61e-156: 532: 14.05
+	Hs
		955389 CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54		DOCK8_HUMAN (753-942): 6.16e-24: 112: 10.40