HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	15536084
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0030183 - B cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 635
+	Hs
		136345 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA5_HUMAN (171-632): 1.78e-115: 371: 25.42
+	Hs
		136299 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA2_HUMAN (175-631): 4.48e-115: 368: 25.81
+	Hs
		136300 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA3_HUMAN (178-632): 9.67e-115: 368: 24.89
+	Hs
		136275 P85B_HUMAN (1-728): 0: 541: 100.00		FGFR1_HUMAN (179-635): 9.93e-116: 366: 26.24
+	Hs
		136394 P85B_HUMAN (1-728): 0: 541: 100.00		NTRK2_HUMAN (158-629): 1.83e-115: 365: 24.36
+	Hs
		136304 P85B_HUMAN (1-728): 0: 541: 100.00		LTK_HUMAN (178-632): 8.04e-111: 354: 25.75
+	Hs
		136346 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA4_HUMAN (329-626): 7.46e-106: 344: 34.54
+	Hs
		136254 P85B_HUMAN (1-728): 0: 541: 100.00		LCK_HUMAN (5-201): 5.99e-74: 247: 23.29
+	Hs
		136276 P85B_HUMAN (1-728): 0: 541: 100.00		SRC_HUMAN (5-371): 3.24e-72: 244: 15.52
+	Hs
		136255 P85B_HUMAN (1-728): 0: 541: 100.00		FYN_HUMAN (5-371): 1.27e-71: 242: 14.90
+	Hs
		136242 P85B_HUMAN (1-728): 0: 541: 100.00		ABL1_HUMAN (6-379): 1.1e-59: 218: 15.84
+	Hs
		72375 P85B_HUMAN (1-728): 0: 541: 100.00		A9UF07_HUMAN (6-379): 1.86e-59: 218: 15.84
+	Hs
		136375 P85B_HUMAN (1-728): 0: 541: 100.00		FAK1_HUMAN (344-626): 1.88e-57: 211: 39.30
+	Hs
		136389 P85B_HUMAN (1-728): 0: 541: 100.00		ERBB4_HUMAN (375-619): 7.17e-57: 210: 43.15
+	Hs
		136243 P85B_HUMAN (1-728): 0: 541: 100.00		EGFR_HUMAN (375-619): 8.77e-57: 209: 43.15
+	Hs
		136250 P85B_HUMAN (1-728): 0: 541: 100.00		ERBB2_HUMAN (375-619): 1.48e-52: 197: 42.34
+	Hs
		136323 P85B_HUMAN (1-728): 0: 541: 100.00		TEC_HUMAN (6-379): 4.77e-49: 183: 13.37
+	Hs
		136264 P85B_HUMAN (1-728): 0: 541: 100.00		HCK_HUMAN (104-310): 5.69e-24: 108: 21.03
+	Hs
		116831 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		I6L996_HUMAN (344-626): 1.15e-58: 210: 39.30
+	Hs
		363648 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		EGFR_HUMAN (375-619): 8.77e-57: 209: 43.15