HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 864
+	Hs
		136448 P85B_HUMAN (1-728): 0: 541: 100.00		ALK_HUMAN (4-851): 0: 701: 54.51
+	Hs
		136261 P85B_HUMAN (1-728): 0: 541: 100.00		RET_HUMAN (278-849): 1.23e-145: 460: 25.98
+	Hs
		136289 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA1_HUMAN (25-817): 3.82e-139: 439: 19.11
+	Hs
		136275 P85B_HUMAN (1-728): 0: 541: 100.00		FGFR1_HUMAN (221-839): 2.46e-139: 435: 20.32
+	Hs
		136290 P85B_HUMAN (1-728): 0: 541: 100.00		FGFR2_HUMAN (222-833): 7.86e-138: 431: 20.62
+	Hs
		136389 P85B_HUMAN (1-728): 0: 541: 100.00		ERBB4_HUMAN (277-846): 5.55e-131: 425: 21.41
+	Hs
		136262 P85B_HUMAN (1-728): 0: 541: 100.00		IGF1R_HUMAN (298-854): 3.96e-128: 419: 27.39
+	Hs
		136302 P85B_HUMAN (1-728): 0: 541: 100.00		EPHB2_HUMAN (391-796): 5.16e-128: 412: 26.21
+	Hs
		136300 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA3_HUMAN (388-798): 1.23e-124: 401: 27.30
+	Hs
		136345 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA5_HUMAN (389-809): 3.85e-124: 401: 26.02
+	Hs
		136253 P85B_HUMAN (1-728): 0: 541: 100.00		INSR_HUMAN (367-837): 3.31e-121: 400: 30.82
+	Hs
		136280 P85B_HUMAN (1-728): 0: 541: 100.00		INSRR_HUMAN (391-827): 1.69e-110: 369: 34.69
+	Hs
		136299 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA2_HUMAN (446-813): 1.15e-109: 361: 30.38
+	Hs
		136394 P85B_HUMAN (1-728): 0: 541: 100.00		NTRK2_HUMAN (475-778): 2.44e-61: 224: 38.07
+	Hs
		136251 P85B_HUMAN (1-728): 0: 541: 100.00		NTRK1_HUMAN (502-786): 7.78e-60: 220: 41.64
+	Hs
		136323 P85B_HUMAN (1-728): 0: 541: 100.00		TEC_HUMAN (504-777): 1.34e-56: 207: 41.52
+	Hs
		136393 P85B_HUMAN (1-728): 0: 541: 100.00		NTRK3_HUMAN (502-778): 1.77e-54: 205: 36.76
+	Hs
		136371 P85B_HUMAN (1-728): 0: 541: 100.00		ROR1_HUMAN (504-778): 1.87e-53: 202: 40.00
+	Hs
		465593 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		IGF1R_HUMAN (298-854): 3.96e-128: 419: 27.39
+	Hs
		412355 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		NTRK1_HUMAN (502-786): 7.78e-60: 220: 41.64