HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: PF21A (Q96BD5)
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
Gene: PHF21A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

Property	Details
Experiments	12032298, 34709266, 15325272, 12493763, 30737378, 35271311, 23752268, 21258344
Identification Methods	biochemical, proximity labelling technology, pull down, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	Hist_deacetyl~PHD
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 680
+	Hs
		180886 HDAC2_HUMAN (1-488): 0: 707: 100.00		TIF1A_HUMAN (2-647): 2.12e-79: 275: 14.56
+	Hs
		1368181 HDAC2_HUMAN (1-488): 0: 707: 100.00		KDM5B_HUMAN (147-656): 1.24e-63: 231: 14.04
+	Hs
		833763 HDAC2_HUMAN (1-488): 0: 707: 100.00		KDM5C_HUMAN (164-655): 1.21e-62: 228: 15.98
+	Hs
		711837 HDAC2_HUMAN (1-488): 0: 707: 100.00		KDM5A_HUMAN (211-656): 2.13e-53: 201: 16.59
+	Mm
		59100 HDAC2_MOUSE (1-488): 0: 704: 99.39		CHD5_MOUSE (255-617): 9.73e-48: 184: 16.33
+	Hs
		1351278 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD5_HUMAN (255-617): 1.44e-43: 171: 16.79
+	Hs
		1132869 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD4_HUMAN (255-650): 3.89e-43: 170: 14.51
+	Mm
		1000005 HDAC2_MOUSE (1-488): 0: 704: 99.39		Q5DTP7_MOUSE (255-650): 1.05e-42: 168: 14.51
+	Hs
		1088484 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD3_HUMAN (297-617): 2.53e-41: 164: 16.57
+	Dm
		1374486 HDAC1_DROME (5-472): 0: 653: 77.92		KDM5_DROME (79-655): 3.11e-59: 218: 12.67
+	Hs
		1368048 HDAC2_HUMAN (1-488): 0: 707: 100.00		PF21B_HUMAN (147-668): 1e-38: 152: 29.66
+	Dm
		356804 HDAC1_DROME (5-472): 0: 653: 77.92		CHDM_DROME (163-626): 6.55e-49: 187: 15.98
+	Mm
		59097 HDAC1_MOUSE (1-443): 0: 645: 90.29		CHD5_MOUSE (255-617): 9.73e-48: 184: 16.33
+	Dm
		72172 HDAC1_DROME (5-472): 0: 653: 77.92		A8WHL4_DROME (97-646): 3.11e-42: 167: 11.30
+	Dm
		1374477 HDAC1_DROME (5-472): 0: 653: 77.92		Q9VDK5_DROME (97-646): 5.29e-40: 160: 11.19
+	Mm
		148708 HDAC1_MOUSE (1-443): 0: 645: 90.29		CHD4_MOUSE (255-650): 9.38e-43: 168: 14.51
+	Hs
		231157 HDAC2_HUMAN (1-488): 0: 707: 100.00		AIRE_HUMAN (472-538): 1.24e-19: 94.9: 43.06
+	Hs
		1368065 HDAC2_HUMAN (1-488): 0: 707: 100.00		PHF12_HUMAN (462-541): 2e-13: 76: 31.71
+	Hs
		355572 HDAC2_HUMAN (1-488): 0: 707: 100.00		NSD2_HUMAN (423-540): 6.19e-09: 61.5: 20.00
+	Dm
		1374503 HDAC1_DROME (5-472): 0: 653: 77.92		Q9W410_DROME (350-607): 1.01e-13: 76.8: 16.86