HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: RGAP1 (Q9H0H5)
Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)
Gene: RACGAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	19531213, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 632
+	Hs
		1430109 CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36		RGAP1_HUMAN (1-632): 0: 533: 100.00
+	Hs
		1279847 SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00		SRGP1_HUMAN (14-627): 3.02e-89: 301: 12.74
+	Hs
		987928 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		RGAP1_HUMAN (1-632): 0: 533: 100.00
+	Hs
		1165236 SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00		RHG44_HUMAN (65-625): 5.73e-75: 258: 14.36
+	Hs
		49975 SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00		RHG10_HUMAN (12-577): 1.06e-72: 251: 16.06
+	Hs
		1256683 SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00		RHG27_HUMAN (328-540): 1e-63: 227: 30.23
+	Hs
		1165243 CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36		RHG44_HUMAN (65-625): 5.73e-75: 258: 14.36
+	Hs
		1121963 ARHG7_HUMAN (2-595): 6.82e-34: 140: 16.23		SRGP1_HUMAN (14-627): 3.02e-89: 301: 12.74
+	Hs
		212764 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		SRGP3_HUMAN (1-627): 3.16e-88: 298: 13.65
+	Hs
		269561 SPD2A_HUMAN (3-650): 8.88e-37: 150: 16.74		SRGP2_HUMAN (14-626): 2.83e-70: 248: 11.95
+	Hs
		593948 NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62		CHIO_HUMAN (204-539): 4.39e-88: 283: 24.37
+	Hs
		586972 NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62		CHIN_HUMAN (239-539): 7.62e-87: 280: 28.20
+	Hs
		222040 NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24		CHIO_HUMAN (204-539): 4.39e-88: 283: 24.37
+	Hs
		222012 NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24		CHIN_HUMAN (239-539): 7.62e-87: 280: 28.20
+	Hs
		987675 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		Q1RLN5_HUMAN (329-541): 9.42e-65: 229: 27.44
+	Hs
		987756 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		RHG12_HUMAN (329-541): 1.95e-64: 229: 27.44
+	Hs
		594020 NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62		RHG21_HUMAN (333-629): 2.11e-63: 229: 26.06
+	Mm
		1221229 GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37		BCR_MOUSE (362-505): 1.77e-19: 95.5: 39.73
+	Hs
		539994 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		BCR_HUMAN (362-505): 1.77e-19: 95.5: 39.73
+	Hs
		292805 GRAP2_HUMAN (1-58): 2.52e-17: 85.5: 31.03		BCR_HUMAN (362-505): 1.77e-19: 95.5: 39.73