HitPredict

Interactor 1: VWCE (Q96DN2)
von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein)
Gene: VWCE

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 955 Hs			1 273
+	Hs
		572688 NID1_HUMAN (92-351): 1.04e-45: 181: 27.27		NID2_HUMAN (5-272): 9.09e-22: 96.8: 11.42
+	Hs
		572677 NID1_HUMAN (92-351): 1.04e-45: 181: 27.27		NID1_HUMAN (60-271): 1.89e-16: 81: 16.46
+	Mm
		1223430 NOTC3_MOUSE (7-582): 9.73e-28: 123: 12.22		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Hs
		1459916 NOTC3_HUMAN (3-533): 4.72e-23: 108: 14.84		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Hs
		1453625 CRIM1_HUMAN (367-783): 2.32e-22: 105: 20.93		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Hs
		1294393 FRAS1_HUMAN (4-669): 1.32e-21: 103: 12.88		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Mm
		204911 NOTC2_MOUSE (439-827): 8.62e-23: 107: 13.57		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Hs
		654564 FBLN1_HUMAN (149-534): 1.44e-20: 99.5: 18.80		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Hs
		654552 FBLN1_HUMAN (149-534): 1.44e-20: 99.5: 18.80		EGFL8_HUMAN (14-273): 5.92e-38: 136: 34.44
+	Hs
		654544 FBLN1_HUMAN (149-534): 1.44e-20: 99.5: 18.80		NELL1_HUMAN (82-180): 4.1e-26: 109: 36.63
+	Hs
		857407 JAG1_HUMAN (273-873): 6.9e-30: 130: 10.06		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57
+	Hs
		572680 FBLN1_HUMAN (149-534): 1.44e-20: 99.5: 18.80		NID1_HUMAN (60-271): 1.89e-16: 81: 16.46
+	Hs
		1008030 NOTC3_HUMAN (3-533): 4.72e-23: 108: 14.84		JAG1_HUMAN (66-168): 2.85e-10: 62.4: 28.57
+	Hs
		857591 NOTC3_HUMAN (3-533): 4.72e-23: 108: 14.84		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57
+	Hs
		857599 JAG2_HUMAN (6-523): 8.69e-23: 107: 12.34		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57
+	Dm
		95089 E1JHA6_DROME (258-795): 4.94e-21: 102: 12.16		NOTCH_DROME (68-172): 2.45e-09: 59.8: 22.32
+	Dm
		451712 NOTCH_DROME (403-867): 1.7e-20: 100: 11.56		NOTCH_DROME (68-172): 2.45e-09: 59.8: 22.32
+	Dm
		451716 NOTCH_DROME (403-867): 1.7e-20: 100: 11.56		DL_DROME (53-168): 3.56e-09: 59: 25.58
+	Hs
		857370 NOTC1_HUMAN (453-881): 2.53e-19: 96.3: 12.41		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57