HitPredict

Interactor 1: TTC1 (Q99614)
Tetratricopeptide repeat protein 1 (TPR repeat protein 1)
Gene: TTC1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 1620
+	Hs
		1432949 UN45A_HUMAN (105-274): 3.78e-43: 159: 27.65		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		711941 UN45A_HUMAN (105-274): 3.78e-43: 159: 27.65		LTK_HUMAN (606-1458): 2.7e-178: 559: 53.24
+	Hs
		464027 SGTB_HUMAN (47-292): 5.57e-38: 137: 19.51		RET_HUMAN (804-1477): 5.87e-139: 460: 23.15
+	Hs
		650414 UN45A_HUMAN (105-274): 3.78e-43: 159: 27.65		FGFR3_HUMAN (952-1449): 2.13e-119: 397: 26.31
+	Hs
		179607 FKBP5_HUMAN (29-273): 9e-44: 156: 17.26		MUSK_HUMAN (983-1391): 1.78e-119: 399: 29.98
+	Hs
		572921 FKBP5_HUMAN (29-273): 9e-44: 156: 17.26		INSRR_HUMAN (1082-1384): 2.39e-70: 262: 43.46
+	Dm
		561267 Q9VH81_DROME (69-287): 3.16e-39: 145: 19.64		7LESS_DROME (1022-1417): 2.19e-67: 254: 36.34
+	Hs
		412606 UN45A_HUMAN (105-274): 3.78e-43: 159: 27.65		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		411877 FKBP5_HUMAN (29-273): 9e-44: 156: 17.26		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		412617 RPAP3_HUMAN (72-252): 8.01e-41: 151: 24.86		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		411766 FKBP4_HUMAN (29-282): 1.46e-41: 150: 18.02		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		597888 FKBP5_HUMAN (29-273): 9e-44: 156: 17.26		FER_HUMAN (1101-1377): 1.54e-59: 223: 40.35
+	Hs
		456104 FKBP5_HUMAN (29-273): 9e-44: 156: 17.26		FES_HUMAN (1114-1384): 4.52e-59: 222: 42.80
+	Hs
		456101 FKBP4_HUMAN (29-282): 1.46e-41: 150: 18.02		FES_HUMAN (1114-1384): 4.52e-59: 222: 42.80
+	Hs
		411635 PPP5_HUMAN (94-287): 1.79e-36: 137: 23.08		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		411811 PPID_HUMAN (48-251): 6.34e-36: 133: 18.14		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		456102 PPID_HUMAN (48-251): 6.34e-36: 133: 18.14		FES_HUMAN (1114-1384): 4.52e-59: 222: 42.80
+	At
		70565 A8MQ88_ARATH (5-221): 5.53e-39: 141: 12.90		BRI1_ARATH (734-1013): 3.27e-21: 103: 11.00
+	At
		1374146 BSK1_ARATH (5-221): 1.63e-35: 135: 13.30		BRL3_ARATH (532-1043): 8.19e-23: 108: 10.57
+	At
		198915 BSK1_ARATH (5-221): 1.63e-35: 135: 13.30		BRI1_ARATH (734-1013): 3.27e-21: 103: 11.00