HitPredict

Interactor 1: PTN23 (Q9H3S7)
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)
Gene: PTPN23

Interactor 2: SH24A (Q9H788)
SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)
Gene: SH2D4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1636 Hs			1 454
+	Hs
		987935 PTN23_HUMAN (1-1636): 0: 1044: 100.00		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Mm
		431378 PDC6I_MOUSE (9-872): 3.5e-165: 525: 23.20		SRC_MOUSE (224-451): 2.45e-41: 156: 14.68
+	Hs
		987797 PDC6I_HUMAN (9-871): 1.58e-167: 531: 22.21		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Mm
		1221266 PDC6I_MOUSE (9-872): 3.5e-165: 525: 23.20		GRB2_MOUSE (310-454): 2.56e-41: 148: 24.83
+	Ce
		759617 ALXA_CAEEL (4-854): 1.2e-143: 467: 21.01		Q95PW9_CAEEL (63-442): 9.04e-54: 186: 15.21
+	Mm
		1298749 PDC6I_MOUSE (9-872): 3.5e-165: 525: 23.20		PLCG2_MOUSE (134-454): 3.31e-28: 120: 14.93
+	Hs
		711115 PTN6_HUMAN (1159-1472): 1.07e-117: 386: 23.96		LCP2_HUMAN (113-433): 3.7e-40: 152: 15.09
+	Hs
		711089 PTN6_HUMAN (1159-1472): 1.07e-117: 386: 23.96		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Hs
		611076 PTN1_HUMAN (1198-1566): 1.28e-119: 385: 26.10		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Hs
		987897 PTN18_HUMAN (1189-1596): 4.13e-116: 376: 25.64		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Hs
		599271 PTN6_HUMAN (1159-1472): 1.07e-117: 386: 23.96		PLCG2_HUMAN (97-454): 5.01e-28: 119: 15.18
+	Hs
		618988 PTN6_HUMAN (1159-1472): 1.07e-117: 386: 23.96		PLCG1_HUMAN (342-454): 1.04e-26: 115: 25.21
+	Hs
		614690 PTPRA_HUMAN (1205-1453): 4.64e-89: 311: 30.83		SHB_HUMAN (159-441): 8.28e-52: 184: 14.53
+	Hs
		699599 PTN6_HUMAN (1159-1472): 1.07e-117: 386: 23.96		P85A_HUMAN (342-445): 3.24e-19: 92.3: 22.02
+	Mm
		711217 PTN6_MOUSE (1159-1472): 4.39e-118: 387: 24.56		KSYK_MOUSE (279-442): 5.98e-16: 82.3: 23.95
+	Mm
		431321 PTPRA_MOUSE (1205-1453): 5.93e-89: 311: 30.83		SRC_MOUSE (224-451): 2.45e-41: 156: 14.68
+	Mm
		611452 PTPRA_MOUSE (1205-1453): 5.93e-89: 311: 30.83		GRB2_MOUSE (310-454): 2.56e-41: 148: 24.83
+	Hs
		614675 PTPRA_HUMAN (1205-1453): 4.64e-89: 311: 30.83		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Hs
		222016 PTPRA_HUMAN (1205-1453): 4.64e-89: 311: 30.83		NCK2_HUMAN (281-428): 1.14e-23: 103: 24.16
+	Hs
		614654 PTPRA_HUMAN (1205-1453): 4.64e-89: 311: 30.83		P85A_HUMAN (342-445): 3.24e-19: 92.3: 22.02