HitPredict

Interactor 1: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Interactor 2: PKHA6 (Q9Y2H5)
Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Gene: PLEKHA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1620 Hs			1 1048
+	Hs
		1437684 ALK_HUMAN (1-1620): 0: 1901: 100.00		PKHA5_HUMAN (1-1012): 6.39e-102: 347: 28.45
+	Hs
		1213103 ALK_HUMAN (1-1620): 0: 1901: 100.00		RHG21_HUMAN (2-1037): 2.51e-46: 184: 10.10
+	Hs
		1437923 ALK_HUMAN (1-1620): 0: 1901: 100.00		PKHA1_HUMAN (47-259): 5.68e-34: 137: 25.00
+	Dm
		1267163 Q7KJ08_DROME (251-1598): 0: 1087: 31.15		Q7KNQ9_DROME (23-287): 1.09e-39: 162: 20.22
+	Hs
		710894 EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26		PKHA5_HUMAN (1-1012): 6.39e-102: 347: 28.45
+	Hs
		465652 IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77		PKHA5_HUMAN (1-1012): 6.39e-102: 347: 28.45
+	Hs
		711908 LTK_HUMAN (606-1458): 2.7e-178: 559: 53.24		MPRIP_HUMAN (2-252): 1.01e-36: 152: 22.53
+	Hs
		710812 EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26		ANK2_HUMAN (153-1043): 5.19e-51: 199: 11.56
+	Mm
		772099 RET_MOUSE (843-1477): 6.28e-129: 433: 23.56		GAB1_MOUSE (55-571): 1.2e-37: 153: 12.57
+	Hs
		710895 EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26		PKHA1_HUMAN (47-259): 5.68e-34: 137: 25.00
+	Hs
		641200 FGFR2_HUMAN (952-1433): 1.46e-122: 406: 25.24		MPRIP_HUMAN (2-252): 1.01e-36: 152: 22.53
+	Hs
		641285 FGFR2_HUMAN (952-1433): 1.46e-122: 406: 25.24		DYN3_HUMAN (24-383): 5.96e-37: 152: 12.97
+	Hs
		650492 FGFR3_HUMAN (952-1449): 2.13e-119: 397: 26.31		DYN3_HUMAN (24-383): 5.96e-37: 152: 12.97
+	Mm
		1455819 FAK2_MOUSE (1061-1496): 1.35e-110: 378: 28.31		ASAP1_MOUSE (30-826): 8.87e-41: 165: 11.89
+	Hs
		439850 INSR_HUMAN (973-1436): 1e-112: 392: 34.25		PKHA1_HUMAN (47-259): 5.68e-34: 137: 25.00
+	Hs
		465655 IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77		PKHA1_HUMAN (47-259): 5.68e-34: 137: 25.00
+	Hs
		411756 NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07		ANK2_HUMAN (153-1043): 5.19e-51: 199: 11.56
+	Mm
		582014 NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22		GAB1_MOUSE (55-571): 1.2e-37: 153: 12.57
+	Hs
		1159508 NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44		MPRIP_HUMAN (2-252): 1.01e-36: 152: 22.53
+	Hs
		411349 NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07		OSBP1_HUMAN (62-484): 8.58e-37: 151: 15.09