HitPredict

Interactor 1: DLDH (O08749)
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase)
Gene: Dld

Interactor 2: ODPX (Q8BKZ9)
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X)
Gene: Pdhx

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29199018, 29222160
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	E3_binding~Pyr_redox_2, E3_binding~Pyr_redox_dim
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006086 - pyruvate decarboxylation to acetyl-CoA GO:0045254 - pyruvate dehydrogenase complex GO:1902493 - acetyltransferase complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 509 Mm			1 501
+	Hs
		132813 DLDH_HUMAN (1-509): 0: 541: 94.89		ODPX_HUMAN (1-501): 0: 564: 83.23
+	Hs
		484346 DLDH_HUMAN (1-509): 0: 541: 94.89		ODB2_HUMAN (1-500): 5.36e-169: 487: 23.97
+	Hs
		484343 DLDH_HUMAN (1-509): 0: 541: 94.89		ODP2_HUMAN (47-500): 1.94e-159: 469: 37.18
+	Dm
		1481392 Q9VVL7_DROME (20-509): 5.15e-168: 486: 67.47		Q9VM14_DROME (6-500): 1.35e-151: 444: 33.53
+	Mm
		148207 DLDH_MOUSE (1-509): 0: 541: 100.00		ODO2_MOUSE (19-500): 4.73e-131: 389: 20.66
+	Hs
		484412 DLDH_HUMAN (1-509): 0: 541: 94.89		ODO2_HUMAN (22-500): 4.62e-130: 387: 23.22
+	Dm
		120129 Q9VVL7_DROME (20-509): 5.15e-168: 486: 67.47		M9PCG1_DROME (6-500): 1.79e-146: 430: 33.20
+	Sc
		484706 DLDH_YEAST (11-508): 1.93e-151: 443: 52.87		ODP2_YEAST (26-500): 2.16e-140: 414: 29.29
+	Gs
		550559 DLDH1_GEOSE (37-508): 1.78e-142: 419: 43.43		ODP2_GEOSE (58-500): 6.12e-139: 408: 25.33
+	Sc
		484716 DLDH_YEAST (11-508): 1.93e-151: 443: 52.87		ODO2_YEAST (50-500): 1.05e-119: 361: 21.71
+	Ec
		497013 DLDH_ECOLI (36-494): 2.32e-127: 381: 41.39		ODO2_ECOLI (54-500): 5.39e-141: 413: 26.55
+	At
		70789 PLPD1_ARATH (9-503): 4.16e-124: 377: 31.43		ODP24_ARATH (37-500): 4.86e-127: 380: 27.75
+	Ss
		1000817 DLDH_SYNY3 (36-501): 2.64e-119: 360: 34.52		P74510_SYNY3 (56-496): 3.77e-121: 363: 23.62
+	Mm
		148194 DLDH_MOUSE (1-509): 0: 541: 100.00		ODP2_MOUSE (12-145): 7.45e-29: 122: 36.57
+	At
		1082139 DLDH1_ARATH (35-508): 1.45e-155: 454: 57.17		ODP21_ARATH (36-279): 4.66e-31: 128: 25.00
+	Ec
		449830 DLDH_ECOLI (36-494): 2.32e-127: 381: 41.39		ODP2_ECOLI (57-131): 4.62e-11: 67.1: 32.00