HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	26701932, 36398662, 22826439
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031410 - cytoplasmic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 903
+	Hs
		150747 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1273604 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		151182 DVL2_HUMAN (1-736): 0: 547: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		124996 DVL2_HUMAN (1-736): 0: 547: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		150752 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		1273633 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		151146 DVL2_HUMAN (1-736): 0: 547: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		124995 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		150684 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		150725 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1192152 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Mm
		93273 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Hs
		1021523 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		151206 DVL2_HUMAN (1-736): 0: 547: 100.00		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Mm
		56830 DVL2_MOUSE (13-736): 0: 550: 96.69		SMUF2_MOUSE (1-358): 2.99e-46: 179: 16.67
+	Hs
		151200 DVL2_HUMAN (1-736): 0: 547: 100.00		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Mm
		1141509 DVL2_MOUSE (13-736): 0: 550: 96.69		SMUF1_MOUSE (1-535): 3.62e-41: 164: 14.07
+	Mm
		56824 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		SMUF2_MOUSE (1-358): 2.99e-46: 179: 16.67
+	Hs
		150723 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76
+	Ce
		1094742 MIG5_CAEEL (12-558): 2.34e-78: 266: 25.85		Q9BKW4_CAEEL (319-581): 6.75e-13: 74.2: 16.33