HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	10882725, 12027890
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 508
+	Mm
		205453 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		EPOR_MOUSE (1-508): 7.19e-140: 414: 81.69
+	Hs
		557076 SRC_HUMAN (35-219): 1.12e-46: 163: 17.13		EPOR_HUMAN (1-508): 8.74e-145: 427: 100.00
+	Hs
		155901 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		GHR_HUMAN (6-482): 1.39e-87: 283: 15.10
+	Hs
		155904 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		PRLR_HUMAN (40-499): 4.22e-85: 276: 18.03
+	Hs
		155902 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		IL2RB_HUMAN (17-488): 2.5e-64: 220: 17.52
+	Hs
		440345 FYN_HUMAN (35-223): 8.76e-47: 163: 14.80		IL7RA_HUMAN (109-477): 4.78e-65: 219: 15.65
+	Hs
		155962 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		CSF3R_HUMAN (14-425): 2.43e-50: 186: 13.92
+	Hs
		473464 HCK_HUMAN (14-223): 1e-48: 168: 16.26		CSF3R_HUMAN (14-425): 2.43e-50: 186: 13.92
+	Mm
		465769 HCK_MOUSE (14-223): 2.73e-47: 164: 15.45		CSF3R_MOUSE (14-399): 4.46e-42: 162: 15.08
+	Hs
		273307 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		IL4RA_HUMAN (48-496): 2.06e-38: 151: 14.78
+	Mm
		205465 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		IL6RB_MOUSE (19-483): 1.95e-33: 137: 13.92
+	Hs
		155963 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		I12R2_HUMAN (40-256): 3.5e-32: 133: 17.27
+	Hs
		155922 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		LEPR_HUMAN (49-259): 5.63e-29: 123: 12.50
+	Hs
		155917 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		IL6RB_HUMAN (64-483): 1.75e-23: 106: 12.72
+	Mm
		205460 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		LEPR_MOUSE (49-258): 1.18e-21: 101: 16.22
+	Mm
		871462 SOCS7_MOUSE (13-221): 4.59e-51: 175: 24.17		LEPR_MOUSE (49-258): 1.18e-21: 101: 16.22
+	Hs
		473376 HCK_HUMAN (14-223): 1e-48: 168: 16.26		IL6RB_HUMAN (64-483): 1.75e-23: 106: 12.72
+	Mm
		871464 SOCS6_MOUSE (34-220): 9.79e-49: 168: 26.32		LEPR_MOUSE (49-258): 1.18e-21: 101: 16.22
+	Hs
		440313 FYN_HUMAN (35-223): 8.76e-47: 163: 14.80		PTPRF_HUMAN (8-269): 5.22e-13: 73.9: 16.31
+	Mm
		59107 FYN_MOUSE (35-223): 2.91e-47: 164: 14.80		PTPRF_MOUSE (6-234): 1.46e-11: 69.2: 17.24