Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: KDM5A (P29375)
Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)
Gene: KDM5A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 37722486
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ARID~PHD, JmjC~PHD, PHD~PHD, PHD~zf-HC5HC2H_2
Common GO terms GO:0000976 - transcription cis-regulatory region binding
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 2 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 5537
Hs

1 1690
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Dm
+ Hs
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025