HitPredict

Interactor 1: KDM6A (O15550)
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
Gene: KDM6A

Interactor 2: KMT2B (Q9UMN6)
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
Gene: KMT2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JmjC~PHD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1401 Hs			1 2715
+	Hs
		194630 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		SET1B_HUMAN (1961-2715): 1.85e-66: 253: 23.84
+	Hs
		194569 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		EZH2_HUMAN (2250-2697): 7.01e-67: 245: 16.51
+	Hs
		194551 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		KMT2A_HUMAN (1780-2715): 1.77e-52: 207: 29.82
+	Hs
		175811 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		SET1A_HUMAN (2571-2715): 1.53e-26: 122: 52.74
+	Hs
		161374 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		KMT2D_HUMAN (396-778): 8.81e-10: 67.2: 20.80
+	Hs
		194588 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		KMT2C_HUMAN (2005-2475): 3.88e-09: 65.1: 11.39
+	Hs
		158679 UTY_HUMAN (1-1393): 0: 1523: 83.49		KMT2D_HUMAN (396-778): 8.81e-10: 67.2: 20.80
+	Hs
		158698 UTY_HUMAN (1-1393): 0: 1523: 83.49		KMT2C_HUMAN (2005-2475): 3.88e-09: 65.1: 11.39
+	Zm
		25548 A0A1D6JFQ5_MAIZE (248-944): 2.52e-31: 136: 11.63		A0A1D6ISR3_MAIZE (2145-2715): 4.29e-75: 277: 18.69
+	Dm
		120169 M9PCJ7_DROME (176-523): 2.28e-40: 164: 42.94		TRR_DROME (1574-1782): 7.57e-62: 238: 30.90
+	Hs
		185732 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		EZH2_HUMAN (2250-2697): 7.01e-67: 245: 16.51
+	Hs
		216559 CDC23_HUMAN (89-333): 4.95e-23: 107: 16.60		SUV91_HUMAN (2389-2714): 4.43e-74: 256: 18.54
+	Sc
		577561 CYC8_YEAST (247-1080): 5.52e-27: 121: 11.61		SET2_YEAST (2496-2714): 1.58e-64: 238: 24.22
+	Dm
		120184 M9PCJ7_DROME (176-523): 2.28e-40: 164: 42.94		Q9W1H0_DROME (1075-1394): 2.07e-41: 170: 19.76
+	Hs
		185624 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		KMT2A_HUMAN (1780-2715): 1.77e-52: 207: 29.82
+	Hs
		1155639 TTC28_HUMAN (255-558): 2.07e-13: 77.7: 11.33		EZH2_HUMAN (2250-2697): 7.01e-67: 245: 16.51
+	Hs
		1041546 CTR9_HUMAN (173-479): 5.74e-17: 89.3: 10.64		KMT2A_HUMAN (1780-2715): 1.77e-52: 207: 29.82
+	Hs
		185837 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		PHF6_HUMAN (1573-1755): 8.56e-33: 134: 19.12
+	Hs
		175810 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		SET1A_HUMAN (2571-2715): 1.53e-26: 122: 52.74
+	Hs
		185866 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		KMT2C_HUMAN (2005-2475): 3.88e-09: 65.1: 11.39