HitPredict

Interactor 1: MUSK (O15146)
Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)
Gene: MUSK

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	22939624, 25036637
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 869 Hs			1 732
+	Hs
		169160 MUSK_HUMAN (1-869): 0: 794: 100.00		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		426974 CSF1R_HUMAN (28-862): 3.54e-155: 481: 20.63		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431568 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431788 MERTK_HUMAN (111-865): 1.2e-148: 465: 22.37		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		426977 CSF1R_HUMAN (28-862): 3.54e-155: 481: 20.63		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437923 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		438114 MERTK_HUMAN (111-865): 1.2e-148: 465: 22.37		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		431435 RET_HUMAN (493-869): 1.79e-118: 388: 33.85		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		499223 KIT_HUMAN (19-865): 5.06e-153: 476: 18.88		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		538120 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		431438 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431488 INSRR_HUMAN (569-852): 5.57e-67: 245: 42.61		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		435497 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437855 INSRR_HUMAN (569-852): 5.57e-67: 245: 42.61		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Dm
		365430 INSR_DROME (539-864): 7.85e-66: 243: 38.34		HSP83_DROME (15-732): 0: 1034: 78.41
+	Hs
		674450 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		H90B3_HUMAN (19-732): 0: 728: 65.41
+	Rn
		544887 INSR_RAT (569-857): 2.08e-69: 253: 42.22		ENPL_RAT (14-701): 0: 901: 46.21
+	Hs
		411287 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		435523 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Dm
		448254 INSR_DROME (539-864): 7.85e-66: 243: 38.34		Q9VAY2_DROME (15-700): 0: 537: 46.13