HitPredict

Interactor 1: PPM1D (O15297)
Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)
Gene: PPM1D

Interactor 2: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	20101220, 20460517, 20118229
Identification Methods	enzymatic study, affinity chromatography technology, phosphatase assay, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 605 Hs			1 143
+	Hs
		273452 PPM1B_HUMAN (51-481): 3.23e-109: 338: 21.22		H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97
+	Hs
		273341 PPM1B_HUMAN (51-481): 3.23e-109: 338: 21.22		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Hs
		273353 PPM1B_HUMAN (51-481): 3.23e-109: 338: 21.22		H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47
+	Hs
		260683 PPM1B_HUMAN (51-481): 3.23e-109: 338: 21.22		H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69