HitPredict

Interactor 1: RGS16 (O15492)
Regulator of G-protein signaling 16 (RGS16) (A28-RGS14P) (Retinal-specific RGS) (RGS-r) (hRGS-r) (Retinally abundant regulator of G-protein signaling)
Gene: RGS16

Interactor 2: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10878019
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 202 Hs			1 354
+	Rn
		500350 RGS4_RAT (1-202): 3.28e-73: 221: 43.56		GNAI1_RAT (1-354): 0: 512: 99.72
+	Hs
		834937 RGS4_HUMAN (1-202): 6.38e-73: 221: 44.06		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		180652 RGS16_HUMAN (1-202): 1.93e-75: 227: 100.00		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		180650 RGS16_HUMAN (1-202): 1.93e-75: 227: 100.00		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		391358 RGS4_HUMAN (1-202): 6.38e-73: 221: 44.06		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		180653 RGS16_HUMAN (1-202): 1.93e-75: 227: 100.00		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		444692 RGS3_HUMAN (16-188): 7.53e-64: 214: 50.87		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Mm
		579645 RGS16_MOUSE (1-202): 7.84e-77: 230: 84.65		GNAO_MOUSE (1-354): 1.59e-172: 485: 71.83
+	Hs
		391357 RGS3_HUMAN (16-188): 7.53e-64: 214: 50.87		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		450989 RGS4_HUMAN (1-202): 6.38e-73: 221: 44.06		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		444693 RGS7_HUMAN (7-196): 7.71e-64: 206: 28.64		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Rn
		834945 RGS4_RAT (1-202): 3.28e-73: 221: 43.56		GNAO_RAT (1-354): 5.14e-173: 486: 71.83
+	Hs
		182439 RGS5_HUMAN (1-182): 8.68e-66: 202: 50.55		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		180656 RGS16_HUMAN (1-202): 1.93e-75: 227: 100.00		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		277782 RGS9_HUMAN (18-195): 1.11e-62: 207: 30.90		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		834936 RGS4_HUMAN (1-202): 6.38e-73: 221: 44.06		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		834946 RGS7_HUMAN (7-196): 7.71e-64: 206: 28.64		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		670435 RGS3_HUMAN (16-188): 7.53e-64: 214: 50.87		GNA11_HUMAN (1-353): 1.33e-162: 460: 51.13
+	Hs
		180658 RGS16_HUMAN (1-202): 1.93e-75: 227: 100.00		GNA13_HUMAN (2-353): 1.72e-155: 443: 39.17
+	Hs
		580410 RGS7_HUMAN (7-196): 7.71e-64: 206: 28.64		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23