HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29991678, 16410555
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 806
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (10-806): 0: 819: 100.00
+	Hs
		855777 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		EPHA4_HUMAN (1-781): 0: 622: 20.78
+	Hs
		146597 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		EPHA2_HUMAN (1-788): 0: 595: 21.50
+	Hs
		147489 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		EPHA2_HUMAN (1-788): 0: 595: 21.50
+	Mm
		193336 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		KIT_MOUSE (11-794): 2.41e-170: 519: 25.06
+	Mm
		193337 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		CSF1R_MOUSE (5-764): 1.87e-167: 511: 27.49
+	Hs
		181778 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		KIT_HUMAN (19-794): 1.17e-165: 506: 24.62
+	Hs
		256847 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		KIT_HUMAN (19-794): 1.17e-165: 506: 24.62
+	Hs
		181810 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FLT3_HUMAN (11-791): 1.67e-162: 499: 23.74
+	Hs
		499278 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		KIT_HUMAN (19-794): 1.17e-165: 506: 24.62
+	Hs
		499291 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		KIT_HUMAN (19-794): 1.17e-165: 506: 24.62
+	Hs
		146585 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		KIT_HUMAN (19-794): 1.17e-165: 506: 24.62
+	Hs
		147481 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		KIT_HUMAN (19-794): 1.17e-165: 506: 24.62
+	Hs
		146603 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		FLT3_HUMAN (11-791): 1.67e-162: 499: 23.74
+	Hs
		147491 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FLT3_HUMAN (11-791): 1.67e-162: 499: 23.74
+	Hs
		146632 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		NTRK2_HUMAN (159-756): 1.53e-161: 491: 25.51
+	Hs
		146579 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Hs
		384538 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Hs
		181846 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TIE2_HUMAN (478-783): 3.47e-72: 258: 44.77
+	Hs
		181766 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		CSF1R_HUMAN (38-359): 3.54e-11: 69: 18.37