HitPredict

Interactor 1: TLN1 (P26039)
Talin-1
Gene: TLN1

Interactor 2: VINC (Q64727)
Vinculin (Metavinculin)
Gene: Vcl

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	20308429
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	VBS~Vinculin
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0005925 - focal adhesion and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2541 Mm			1 1066
+	Hs
		575878 TLN1_HUMAN (1-2541): 0: 1492: 98.74		VINC_HUMAN (1-1066): 0: 802: 90.56
+	Gg
		517022 TLN1_CHICK (1-2541): 0: 1419: 89.06		VINC_CHICK (1-1066): 0: 793: 86.96
+	Hs
		1377797 TLN1_HUMAN (1-2541): 0: 1492: 98.74		TLN2_HUMAN (13-1036): 1.58e-38: 159: 12.25
+	Ce
		103456 G4S9F5_CAEEL (683-2537): 0: 749: 34.15		VINC_CAEEL (1-1064): 0: 654: 29.87
+	Hs
		575726 DYST_HUMAN (389-2525): 4.68e-167: 581: 12.01		VINC_HUMAN (1-1066): 0: 802: 90.56
+	Hs
		575872 MACF1_HUMAN (441-2519): 1.4e-152: 535: 10.69		VINC_HUMAN (1-1066): 0: 802: 90.56
+	Hs
		575856 E41L5_HUMAN (50-684): 4.44e-97: 333: 14.02		VINC_HUMAN (1-1066): 0: 802: 90.56
+	Hs
		575691 MOES_HUMAN (163-404): 7.36e-52: 196: 23.05		VINC_HUMAN (1-1066): 0: 802: 90.56
+	Hs
		716807 MACF1_HUMAN (441-2519): 1.4e-152: 535: 10.69		CTNA1_HUMAN (5-907): 6.98e-72: 259: 15.33
+	Dm
		220703 Q8MQJ8_DROME (1675-2531): 8.27e-134: 453: 16.90		VINC_DROME (1-713): 4.27e-77: 275: 32.56
+	Dm
		220700 Q86BS5_DROME (1675-2531): 4.01e-133: 450: 16.90		VINC_DROME (1-713): 4.27e-77: 275: 32.56
+	Hs
		546950 EZRI_HUMAN (84-650): 4.79e-86: 296: 14.41		CTNA1_HUMAN (5-907): 6.98e-72: 259: 15.33
+	Hs
		547257 EZRI_HUMAN (84-650): 4.79e-86: 296: 14.41		CTNL1_HUMAN (659-1052): 2.48e-57: 213: 15.10
+	Dm
		1098344 MERH_DROME (83-671): 1.36e-110: 370: 18.15		Q9VSL8_DROME (622-1032): 3.98e-11: 69.6: 15.06
+	Dm
		114276 MERH_DROME (83-671): 1.36e-110: 370: 18.15		M9PBW9_DROME (622-1032): 3.97e-11: 69.6: 15.06
+	Hs
		716672 MYO7A_HUMAN (83-365): 1.03e-16: 89.9: 18.71		CTNA1_HUMAN (5-907): 6.98e-72: 259: 15.33
+	Hs
		716744 FERM2_HUMAN (268-416): 1.72e-11: 72: 27.82		CTNA1_HUMAN (5-907): 6.98e-72: 259: 15.33