HitPredict

Interactor 1: KDM6A (O15550)
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
Gene: KDM6A

Interactor 2: SET1B (Q9UPS6)
Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)
Gene: SETD1B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1401 Hs			1 1966
+	Hs
		194629 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		KMT2B_HUMAN (1069-1966): 4.74e-71: 268: 21.69
+	Hs
		194551 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		KMT2A_HUMAN (1173-1966): 2.65e-66: 252: 21.73
+	Hs
		194569 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		EZH2_HUMAN (1460-1950): 4.9e-69: 250: 15.69
+	Hs
		194588 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		KMT2C_HUMAN (1759-1966): 1.3e-58: 227: 37.04
+	Hs
		175811 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		SET1A_HUMAN (409-1966): 4.11e-55: 215: 22.38
+	Hs
		161374 KDM6A_HUMAN (1-1401): 0: 1667: 100.00		KMT2D_HUMAN (1826-1966): 3.09e-17: 91.3: 46.85
+	Hs
		158698 UTY_HUMAN (1-1393): 0: 1523: 83.49		KMT2C_HUMAN (1759-1966): 1.3e-58: 227: 37.04
+	Hs
		158679 UTY_HUMAN (1-1393): 0: 1523: 83.49		KMT2D_HUMAN (1826-1966): 3.09e-17: 91.3: 46.85
+	Dm
		120169 M9PCJ7_DROME (176-523): 2.28e-40: 164: 42.94		TRR_DROME (1759-1966): 1.75e-65: 249: 35.62
+	Zm
		25548 A0A1D6JFQ5_MAIZE (248-944): 2.52e-31: 136: 11.63		A0A1D6ISR3_MAIZE (1598-1966): 7.1e-73: 269: 28.75
+	Hs
		185624 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		KMT2A_HUMAN (1173-1966): 2.65e-66: 252: 21.73
+	Hs
		185732 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		EZH2_HUMAN (1460-1950): 4.9e-69: 250: 15.69
+	Mm
		1297452 OGT1_MOUSE (255-640): 7.94e-29: 127: 10.91		NSD2_MOUSE (1654-1965): 8.88e-65: 245: 22.15
+	Hs
		216559 CDC23_HUMAN (89-333): 4.95e-23: 107: 16.60		SUV91_HUMAN (1659-1965): 4.91e-74: 255: 17.05
+	Sc
		577561 CYC8_YEAST (247-1080): 5.52e-27: 121: 11.61		SET2_YEAST (1749-1965): 6.27e-64: 235: 23.68
+	Hs
		185866 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		KMT2C_HUMAN (1759-1966): 1.3e-58: 227: 37.04
+	Hs
		175810 OGT1_HUMAN (255-640): 7.42e-29: 127: 10.91		SET1A_HUMAN (409-1966): 4.11e-55: 215: 22.38
+	Hs
		1041546 CTR9_HUMAN (173-479): 5.74e-17: 89.3: 10.64		KMT2A_HUMAN (1173-1966): 2.65e-66: 252: 21.73
+	Hs
		1155639 TTC28_HUMAN (255-558): 2.07e-13: 77.7: 11.33		EZH2_HUMAN (1460-1950): 4.9e-69: 250: 15.69
+	Hs
		718547 CDC27_HUMAN (96-315): 1.8e-11: 71: 23.18		KMT2A_HUMAN (1173-1966): 2.65e-66: 252: 21.73