HitPredict

Interactor 1: SOCS2 (O35717)
Suppressor of cytokine signaling 2 (SOCS-2)
Gene: SOCS2

Interactor 2: LEPR (P48356)
Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295)
Gene: LEPR

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.80	0.665

Property	Details
Experiments	16684815, 16698021
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Mm			1 1162
+	Mm
		871462 SOCS7_MOUSE (31-196): 1.49e-50: 173: 31.03		LEPR_MOUSE (1-1162): 0: 1002: 100.00
+	Mm
		205460 SOCS3_MOUSE (28-194): 6.94e-49: 160: 29.59		LEPR_MOUSE (1-1162): 0: 1002: 100.00
+	Mm
		871461 CISH_MOUSE (12-198): 6.17e-41: 141: 36.92		LEPR_MOUSE (1-1162): 0: 1002: 100.00
+	Mm
		871464 SOCS6_MOUSE (26-196): 1.84e-37: 137: 30.90		LEPR_MOUSE (1-1162): 0: 1002: 100.00
+	Hs
		155922 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		LEPR_HUMAN (1-1162): 0: 954: 75.39
+	Hs
		440371 FYN_HUMAN (14-172): 7.77e-43: 152: 15.48		PTPRD_HUMAN (28-931): 4.97e-90: 322: 13.89
+	Hs
		440539 FYN_HUMAN (14-172): 7.77e-43: 152: 15.48		PTPRS_HUMAN (37-1050): 2.52e-88: 316: 12.12
+	Hs
		440313 FYN_HUMAN (14-172): 7.77e-43: 152: 15.48		PTPRF_HUMAN (24-866): 1.07e-82: 299: 12.00
+	Mm
		59107 FYN_MOUSE (14-172): 7.01e-43: 152: 15.48		PTPRF_MOUSE (24-866): 2.42e-82: 298: 12.37
+	Hs
		439918 LCK_HUMAN (3-171): 8.16e-38: 138: 17.98		PTPRF_HUMAN (24-866): 1.07e-82: 299: 12.00
+	Dm
		362461 ABL_DROME (1-173): 2.04e-39: 144: 18.18		LAR_DROME (224-861): 3.83e-52: 203: 15.08
+	Hs
		155073 SOCS2_HUMAN (1-198): 2.9e-64: 198: 93.94		PRLR_HUMAN (425-624): 5.83e-15: 81.7: 22.86
+	Mm
		205465 SOCS3_MOUSE (28-194): 6.94e-49: 160: 29.59		IL6RB_MOUSE (268-883): 1.17e-17: 91.1: 13.57
+	Hs
		155917 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		IL6RB_HUMAN (426-883): 3.45e-16: 86: 14.75
+	Hs
		155904 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		PRLR_HUMAN (425-624): 5.83e-15: 81.7: 22.86
+	Hs
		155963 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		I12R2_HUMAN (501-819): 9.5e-11: 68.3: 13.86
+	Hs
		473376 HCK_HUMAN (1-171): 9.01e-40: 143: 13.33		IL6RB_HUMAN (426-883): 3.45e-16: 86: 14.75
+	Hs
		155962 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		CSF3R_HUMAN (249-880): 1.03e-09: 64.9: 11.93
+	Mm
		465769 HCK_MOUSE (1-174): 6.27e-40: 144: 13.66		CSF3R_MOUSE (186-662): 5.11e-11: 69.1: 13.55
+	Hs
		473464 HCK_HUMAN (1-171): 9.01e-40: 143: 13.33		CSF3R_HUMAN (249-880): 1.03e-09: 64.9: 11.93