HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.682

Property	Details
Experiments	35509820, 35256949, 16096643, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding GO:0098793 - presynapse
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 246
+	Hs
		227067 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		227056 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Mm
		935714 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		1433F_MOUSE (1-246): 6.15e-136: 383: 99.19
+	Hs
		227114 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		226644 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		226580 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		226645 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20
+	At
		788526 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		14333_ARATH (1-244): 1.01e-141: 398: 61.38
+	At
		965293 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		14332_ARATH (4-244): 8.72e-141: 396: 60.91
+	At
		788352 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		14331_ARATH (4-244): 2.19e-140: 395: 59.67
+	At
		802003 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		14334_ARATH (4-244): 5.36e-139: 392: 60.49
+	Hs
		475565 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		475596 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		475393 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		475365 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43