HitPredict

Interactor 1: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Interactor 2: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, Ank_2~SH3_9
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 671 Hs			1 168
+	Hs
		920439 SPTN1_HUMAN (107-622): 3.6e-38: 154: 13.98		DAPK1_HUMAN (42-168): 7.96e-30: 116: 20.93
+	Hs
		1091395 SPTN1_HUMAN (107-622): 3.6e-38: 154: 13.98		ANK3_HUMAN (77-168): 2.7e-25: 103: 41.30
+	Hs
		1154184 ITSN1_HUMAN (183-669): 3.58e-27: 120: 15.41		RAI14_HUMAN (1-135): 1.92e-37: 137: 21.32
+	Hs
		1030639 SPTN1_HUMAN (107-622): 3.6e-38: 154: 13.98		ANK2_HUMAN (77-168): 9.69e-24: 98.4: 40.22
+	Mm
		86327 B9EKJ1_MOUSE (107-622): 8.92e-37: 150: 13.98		ANK3_MOUSE (77-168): 4.39e-24: 99.6: 42.39
+	Mm
		597663 SPTN1_MOUSE (107-622): 1.21e-36: 150: 13.98		ANK2_MOUSE (77-168): 9.68e-24: 98.4: 40.22
+	Hs
		1124744 SRC8_HUMAN (485-669): 2.53e-19: 93.9: 15.14		RAI14_HUMAN (1-135): 1.92e-37: 137: 21.32
+	Hs
		1453800 PACN2_HUMAN (520-671): 8.26e-17: 85.8: 20.51		RAI14_HUMAN (1-135): 1.92e-37: 137: 21.32
+	Rn
		591441 SPTN1_RAT (107-622): 2.39e-37: 152: 14.16		TANC1_RAT (82-168): 3.17e-12: 65.3: 22.47
+	Hs
		987991 GRB2_HUMAN (616-669): 7.67e-14: 73.2: 29.09		RAI14_HUMAN (1-135): 1.92e-37: 137: 21.32
+	Hs
		920441 SRC8_HUMAN (485-669): 2.53e-19: 93.9: 15.14		DAPK1_HUMAN (42-168): 7.96e-30: 116: 20.93
+	Hs
		1154121 ITSN1_HUMAN (183-669): 3.58e-27: 120: 15.41		MIB1_HUMAN (74-168): 2.85e-14: 71.5: 21.88
+	Hs
		1352635 SH3R3_HUMAN (42-669): 2.15e-15: 82.3: 11.59		TANC2_HUMAN (17-164): 5.58e-27: 107: 22.50
+	Mm
		59626 SRC8_MOUSE (431-669): 1.37e-18: 91.6: 15.90		A2AM57_MOUSE (43-168): 2.45e-23: 97.5: 25.78
+	Hs
		987550 GRB2_HUMAN (616-669): 7.67e-14: 73.2: 29.09		ANK2_HUMAN (77-168): 9.69e-24: 98.4: 40.22
+	Mm
		1296759 ASAP1_MOUSE (260-668): 3.07e-18: 91.7: 14.73		ANS1B_MOUSE (59-156): 6.95e-16: 75.9: 37.00
+	Hs
		274251 ITSN2_HUMAN (218-671): 7.18e-13: 74.2: 10.61		ANR17_HUMAN (3-166): 8.65e-19: 84.5: 20.10
+	Mm
		1298557 ASAP1_MOUSE (260-668): 3.07e-18: 91.7: 14.73		UACA_MOUSE (7-97): 2.44e-11: 62.8: 23.91
+	Hs
		1280000 CD2AP_HUMAN (614-671): 1.52e-10: 66.5: 27.12		ANS1B_HUMAN (59-156): 6.68e-16: 76.3: 37.00
+	Hs
		987867 GRB2_HUMAN (616-669): 7.67e-14: 73.2: 29.09		EHMT2_HUMAN (107-168): 8.69e-09: 55.3: 22.22