HitPredict

Interactor 1: PHF2 (O75151)
Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)
Gene: PHF2

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30554943
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~PHD
Common GO terms	GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1096 Hs			1 726
+	Hs
		1141365 PHF8_HUMAN (1-1096): 0: 903: 47.35		BRD3_HUMAN (1-702): 1.03e-155: 470: 100.00
+	Hs
		272796 PHF2_HUMAN (1-1096): 0: 919: 100.00		BRD2_HUMAN (5-700): 8.79e-139: 429: 57.95
+	Hs
		260617 PHF8_HUMAN (1-1096): 0: 903: 47.35		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		1461510 PHF8_HUMAN (1-1096): 0: 903: 47.35		BRPF3_HUMAN (20-316): 1.15e-29: 128: 14.29
+	Hs
		260631 KDM2A_HUMAN (54-926): 0: 651: 19.24		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		639850 PHF8_HUMAN (1-1096): 0: 903: 47.35		TAF1_HUMAN (20-303): 4.78e-19: 94.5: 13.73
+	Hs
		1067859 KDM2A_HUMAN (54-926): 0: 651: 19.24		EP300_HUMAN (4-177): 1.06e-35: 148: 23.43
+	Sp
		314557 JHD1_SCHPO (91-899): 7.73e-172: 531: 19.40		YK82_SCHPO (23-148): 2.08e-27: 120: 34.11
+	Sp
		314591 JHD1_SCHPO (91-899): 7.73e-172: 531: 19.40		BDF1_SCHPO (224-481): 2.42e-25: 113: 22.69
+	Hs
		1129599 MDC1_HUMAN (425-1089): 6.66e-30: 131: 12.88		BRD3_HUMAN (1-702): 1.03e-155: 470: 100.00
+	Sp
		314589 JHD1_SCHPO (91-899): 7.73e-172: 531: 19.40		GCN5_SCHPO (331-412): 7.82e-09: 60.5: 32.93
+	Hs
		674162 MDC1_HUMAN (425-1089): 6.66e-30: 131: 12.88		BRD2_HUMAN (5-700): 8.79e-139: 429: 57.95
+	Hs
		259949 MDC1_HUMAN (425-1089): 6.66e-30: 131: 12.88		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		260385 DIDO1_HUMAN (5-92): 3.09e-20: 99.7: 30.44		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		259864 BPTF_HUMAN (6-61): 1.52e-18: 94.2: 48.21		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		1067330 MDC1_HUMAN (425-1089): 6.66e-30: 131: 12.88		EP300_HUMAN (4-177): 1.06e-35: 148: 23.43
+	Hs
		1067781 CXXC1_HUMAN (5-126): 2.48e-26: 117: 31.15		EP300_HUMAN (4-177): 1.06e-35: 148: 23.43
+	Mm
		107078 FXL19_MOUSE (645-1070): 1.15e-24: 112: 14.25		F8VPR5_MOUSE (15-177): 6.82e-34: 142: 24.39
+	Sc
		777101 SPP1_YEAST (4-133): 2.68e-28: 119: 21.33		BDF1_YEAST (47-185): 4e-21: 100: 26.62
+	Zm
		83683 B6TK34_MAIZE (5-59): 1.74e-25: 108: 30.91		K7TPV5_MAIZE (313-409): 1.51e-14: 79: 46.39