HitPredict

Interactor 1: RAD17 (O75943)
Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)
Gene: RAD17

Interactor 2: RFC5 (P40937)
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
Gene: RFC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.948

Property	Details
Experiments	28514442, 33961781, 14605214, 35271311, 14624239, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AAA~Rad17
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 681 Hs			1 340
+	Hs
		298577 RAD17_HUMAN (1-681): 0: 819: 100.00		RFC4_HUMAN (1-331): 1.3e-88: 271: 36.77
+	Hs
		298578 RAD17_HUMAN (1-681): 0: 819: 100.00		RFC2_HUMAN (2-331): 6.18e-86: 264: 35.35
+	Hs
		298581 RAD17_HUMAN (1-681): 0: 819: 100.00		RFC3_HUMAN (21-340): 2.05e-61: 201: 24.00
+	Hs
		769933 RFC1_HUMAN (36-495): 7.88e-72: 254: 14.93		RFC5_HUMAN (1-340): 8.98e-102: 304: 100.00
+	Hs
		769669 RFC4_HUMAN (58-407): 5.91e-75: 247: 15.45		RFC5_HUMAN (1-340): 8.98e-102: 304: 100.00
+	Sp
		152480 RAD17_SCHPO (42-529): 5.46e-76: 257: 23.61		RFC3_SCHPO (17-338): 4.4e-88: 269: 52.48
+	Hs
		769667 RFC1_HUMAN (36-495): 7.88e-72: 254: 14.93		RFC4_HUMAN (1-331): 1.3e-88: 271: 36.77
+	Hs
		769815 RFC1_HUMAN (36-495): 7.88e-72: 254: 14.93		RFC2_HUMAN (2-331): 6.18e-86: 264: 35.35
+	Zm
		78939 B4FQT5_MAIZE (88-449): 1.08e-76: 251: 14.99		B4FJC2_MAIZE (18-340): 2.46e-85: 263: 56.75
+	At
		1373692 RFC4_ARATH (86-429): 1.94e-78: 255: 14.61		RFC5_ARATH (13-340): 2.28e-82: 256: 55.92
+	Hs
		769666 RFC4_HUMAN (58-407): 5.91e-75: 247: 15.45		RFC2_HUMAN (2-331): 6.18e-86: 264: 35.35
+	Sc
		800952 RFC2_YEAST (81-429): 2.43e-75: 247: 15.60		RFC3_YEAST (9-334): 5.12e-83: 256: 49.10
+	Sp
		314176 RAD17_SCHPO (42-529): 5.46e-76: 257: 23.61		RFC4_SCHPO (3-330): 2.48e-78: 244: 35.46
+	Dm
		916510 Q9VX15_DROME (65-413): 1.34e-74: 246: 14.61		RFC2_DROME (6-334): 1.69e-82: 255: 34.85
+	Sp
		896118 RAD17_SCHPO (42-529): 5.46e-76: 257: 23.61		RFC2_SCHPO (6-331): 2.89e-77: 242: 37.91
+	Sc
		822950 RFC2_YEAST (81-429): 2.43e-75: 247: 15.60		RFC4_YEAST (20-329): 5.54e-71: 225: 35.26
+	Sp
		314764 RAD17_SCHPO (42-529): 5.46e-76: 257: 23.61		RFC5_SCHPO (20-330): 1.57e-60: 199: 22.83
+	Hs
		769934 RFC1_HUMAN (36-495): 7.88e-72: 254: 14.93		RFC3_HUMAN (21-340): 2.05e-61: 201: 24.00
+	Hs
		769670 RFC4_HUMAN (58-407): 5.91e-75: 247: 15.45		RFC3_HUMAN (21-340): 2.05e-61: 201: 24.00
+	Sc
		796704 RFC2_YEAST (81-429): 2.43e-75: 247: 15.60		RFC5_YEAST (21-334): 3.53e-60: 198: 23.51