HitPredict

Interactor 1: CDK14 (O94921)
Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)
Gene: CDK14

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 724
+	Hs
		300620 CDK14_HUMAN (1-469): 8.61e-164: 472: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437908 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438075 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431549 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438101 CDK18_HUMAN (3-466): 7.76e-132: 391: 45.69		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431741 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438077 CDK5_HUMAN (132-425): 1.23e-130: 381: 52.70		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438445 CDK15_HUMAN (87-459): 4.79e-128: 380: 60.86		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431772 CDK18_HUMAN (3-466): 7.76e-132: 391: 45.69		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438004 CDK7_HUMAN (129-467): 2.78e-128: 377: 37.61		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431743 CDK5_HUMAN (132-425): 1.23e-130: 381: 52.70		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		414683 CDK1_HUMAN (132-422): 3.66e-130: 380: 48.30		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		432173 CDK15_HUMAN (87-459): 4.79e-128: 380: 60.86		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431662 CDK7_HUMAN (129-467): 2.78e-128: 377: 37.61		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		538107 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		1123456 CDK15_HUMAN (87-459): 4.79e-128: 380: 60.86		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		841224 CDK7_HUMAN (129-467): 2.78e-128: 377: 37.61		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		960099 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		1123433 CDK15_HUMAN (87-459): 4.79e-128: 380: 60.86		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		841223 CDK7_HUMAN (129-467): 2.78e-128: 377: 37.61		H90B4_HUMAN (25-596): 0: 639: 71.85