HitPredict

Interactor 1: A0A0S2Z4E4 (A0A0S2Z4E4)
NCK adaptor protein 1 isoform 3
Gene: NCK1

Interactor 2: ABI2 (Q9NYB9)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	26871637
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration GO:0035591 - signaling adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 244 Hs			1 513
+	Hs
		3136 A0A0S2Z4D7_HUMAN (1-132): 1.7e-42: 144: 100.00		ABI2_HUMAN (1-513): 1.82e-91: 290: 100.00
+	Mm
		70555 B2RQ57_MOUSE (112-225): 1.16e-30: 121: 27.34		ABI1_MOUSE (1-513): 2.82e-100: 312: 60.04
+	Mm
		337634 ABL1_MOUSE (112-225): 4.4e-30: 119: 26.62		ABI1_MOUSE (1-513): 2.82e-100: 312: 60.04
+	Hs
		789078 ABL2_HUMAN (112-225): 4.09e-31: 122: 27.34		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Hs
		337502 ABL1_HUMAN (112-225): 3.4e-30: 120: 26.62		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Hs
		789094 ABL2_HUMAN (112-225): 4.09e-31: 122: 27.34		ABI2_HUMAN (1-513): 1.82e-91: 290: 100.00
+	Hs
		337572 ABL1_HUMAN (112-225): 3.4e-30: 120: 26.62		ABI2_HUMAN (1-513): 1.82e-91: 290: 100.00
+	Dm
		337662 ABL_DROME (112-224): 2.01e-31: 123: 27.34		Q9Y0S9_DROME (1-507): 5.88e-73: 240: 34.91
+	Hs
		275240 GRAP2_HUMAN (109-233): 6.91e-41: 144: 30.77		ASAP1_HUMAN (65-510): 8.77e-43: 165: 14.66
+	Hs
		337590 ABL1_HUMAN (112-225): 3.4e-30: 120: 26.62		ASAP1_HUMAN (65-510): 8.77e-43: 165: 14.66
+	Dm
		993202 GRAP_DROME (109-232): 3.44e-43: 147: 35.42		Q9VDF4_DROME (253-508): 4.51e-34: 137: 20.15
+	Hs
		789066 ABL2_HUMAN (112-225): 4.09e-31: 122: 27.34		SRC8_HUMAN (271-507): 2.78e-32: 131: 17.84
+	Hs
		337333 ABL1_HUMAN (112-225): 3.4e-30: 120: 26.62		VAV_HUMAN (276-513): 8.6e-32: 131: 17.86
+	Hs
		275185 GRAP2_HUMAN (109-233): 6.91e-41: 144: 30.77		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		782767 CSK_HUMAN (69-238): 1.25e-33: 127: 20.23		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		298959 ABL2_HUMAN (112-225): 4.09e-31: 122: 27.34		SRBS2_HUMAN (373-509): 1.11e-16: 85.5: 19.87
+	Hs
		789054 ABL2_HUMAN (112-225): 4.09e-31: 122: 27.34		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		298944 ABL1_HUMAN (112-225): 3.4e-30: 120: 26.62		SRBS2_HUMAN (373-509): 1.11e-16: 85.5: 19.87
+	Hs
		337418 ABL1_HUMAN (112-225): 3.4e-30: 120: 26.62		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		924502 PTN11_HUMAN (144-244): 6.72e-27: 110: 32.04		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93