HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	25402006, 24658140, 16273093, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, unspecified method, ubiquitin reconstruction, protein array, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 258
+	Hs
		155060 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS2_HUMAN (45-258): 1.75e-55: 178: 37.85
+	Mm
		431341 EGFR_MOUSE (1-1210): 0: 1267: 90.35		SRC_MOUSE (50-248): 2.3e-43: 155: 16.11
+	Mm
		236701 EGFR_MOUSE (1-1210): 0: 1267: 90.35		SOCS5_MOUSE (59-257): 2.5e-40: 147: 25.87
+	Rn
		1455868 Q9QX70_RAT (1-1210): 0: 1250: 90.34		SRC_RAT (50-248): 1.38e-43: 156: 16.11
+	Hs
		155889 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS3_HUMAN (44-254): 4.65e-48: 160: 32.42
+	Hs
		155989 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS6_HUMAN (46-256): 5.94e-45: 160: 26.15
+	Hs
		362594 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LCK_HUMAN (10-215): 2.7e-44: 157: 13.55
+	Hs
		362614 EGFR_HUMAN (1-1210): 0: 1246: 100.00		YES_HUMAN (50-213): 7.82e-44: 157: 16.28
+	Hs
		362677 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SRC_HUMAN (50-248): 1.46e-43: 156: 16.11
+	Hs
		362630 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HCK_HUMAN (47-215): 3.81e-43: 155: 15.82
+	Hs
		362647 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FGR_HUMAN (39-213): 1.19e-42: 153: 15.85
+	Hs
		363183 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ITK_HUMAN (7-247): 2.12e-41: 151: 14.77
+	Hs
		362927 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FRK_HUMAN (12-250): 2.14e-41: 150: 12.99
+	Hs
		273298 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS5_HUMAN (45-257): 3.51e-41: 149: 24.65
+	Hs
		193165 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS1_HUMAN (55-258): 2.01e-42: 145: 28.16
+	Mm
		767011 EGFR_MOUSE (1-1210): 0: 1267: 90.35		PTN11_MOUSE (77-222): 1.03e-26: 110: 19.46
+	Hs
		363169 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTN11_HUMAN (77-222): 1.03e-26: 110: 19.46
+	Hs
		362816 EGFR_HUMAN (1-1210): 0: 1246: 100.00		P85A_HUMAN (52-183): 3.37e-22: 97.2: 16.67
+	Hs
		136243 EGFR_HUMAN (1-1210): 0: 1246: 100.00		P85B_HUMAN (52-183): 5.43e-22: 96.8: 17.42
+	Hs
		362615 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LYN_HUMAN (41-209): 8.3e-18: 84.2: 19.21