HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: WDR3 (Q9UNX4)
WD repeat-containing protein 3
Gene: WDR3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 36424410, 25452129
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 943
+	Hs
		406801 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		WDR3_HUMAN (1-943): 0: 660: 100.00
+	Hs
		1155134 USF2_HUMAN (180-454): 2.9e-34: 133: 15.99		WDR3_HUMAN (1-943): 0: 660: 100.00
+	Hs
		371880 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		TBL3_HUMAN (2-576): 5.07e-99: 330: 15.49
+	Hs
		371397 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		LIS1_HUMAN (187-484): 4.73e-50: 184: 11.78
+	Hs
		372767 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		FBXW7_HUMAN (143-519): 5.01e-37: 151: 17.48
+	Mm
		373704 MYC_MOUSE (1-454): 1.16e-117: 353: 89.01		FBXW7_MOUSE (143-519): 4.2e-37: 151: 18.77
+	Hs
		372659 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		UTP15_HUMAN (218-514): 3.65e-24: 109: 12.67
+	Hs
		371643 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		WDR5_HUMAN (1-93): 1.46e-16: 84.2: 17.35
+	Hs
		270295 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		WDR1_HUMAN (646-835): 7.9e-16: 83.8: 9.69
+	Hs
		372082 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		PWP2_HUMAN (12-139): 2.19e-09: 63.4: 17.99
+	Hs
		373290 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		NLE1_HUMAN (748-844): 4.66e-09: 61.8: 4.08
+	Hs
		406466 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		FBXW7_HUMAN (143-519): 5.01e-37: 151: 17.48
+	Mm
		1189859 SRBP2_MOUSE (124-446): 1.15e-36: 145: 13.60		FBXW7_MOUSE (143-519): 4.2e-37: 151: 18.77
+	Mm
		1353851 SRBP1_MOUSE (172-453): 7.23e-35: 140: 16.61		FBXW7_MOUSE (143-519): 4.2e-37: 151: 18.77
+	Hs
		787890 SRBP1_HUMAN (95-453): 7.2e-33: 134: 16.19		FBXW7_HUMAN (143-519): 5.01e-37: 151: 17.48
+	Hs
		405975 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		WDR5_HUMAN (1-93): 1.46e-16: 84.2: 17.35
+	Hs
		406622 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		SKI8_HUMAN (486-703): 8.07e-10: 63.2: 25.56
+	Hs
		648344 USF1_HUMAN (175-453): 3.38e-39: 145: 18.06		WDR5_HUMAN (1-93): 1.46e-16: 84.2: 17.35
+	Dm
		1489024 MYC_DROME (210-454): 1.35e-29: 124: 26.74		FBXW7_DROME (540-707): 6.02e-09: 62.4: 25.29
+	Hs
		269123 MITF_HUMAN (155-450): 1.04e-28: 120: 14.15		FBW1B_HUMAN (72-221): 4.14e-09: 62.4: 29.87