HitPredict

Interactor 1: CO2 (P06681)
Complement C2 (C3/C5 convertase) [Cleaved into: Complement C2a; Serine protease complement C2b (EC 3.4.21.43)]
Gene: C2

Interactor 2: MASP1 (P48740)
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
Gene: MASP1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.33 1.00 0.575

The method score is based on:

Property Details
Experiments 11527969
Identification Methods protease assay
Interaction Type cleavage reaction

The annotation score is based on:

Property Details
Interacting Pfam domains CUB~Sushi, Sushi~Sushi, Sushi~Trypsin, CUB~Trypsin, Trypsin~Trypsin, Sushi~VWA, Trypsin~VWA
Common GO terms GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006508 - proteolysis
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Last updated: 11Aug2025