Interactor 1: BMP2 (P12643)
Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
Gene: BMP2

Interactor 2: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.939

The method score is based on:

Property Details
Experiments 18070108, 16672363, 10880444, 25938661, 17483092, 17295905
Identification Methods pull down, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~TGF_beta
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0009986 - cell surface
GO:0030501 - positive regulation of bone mineralization
GO:0030509 - BMP signaling pathway
GO:0042475 - odontogenesis of dentin-containing tooth
and 4 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 396
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024