Protein: KS6A4
Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)

Gene: KS6A4, RPS6KA4
Organism: Homo sapiens
Interactions: 89
UniProt ID: O75676

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001818 - negative regulation of cytokine production
GO:0004674 - protein serine/threonine kinase activity
GO:0004711 - ribosomal protein S6 kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

290319

MK14
Mitogen-activated protein kinase 14

11

20

Small-scale

0.980

High

290348

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

4

15

High-throughput

0.903

High

290297

MK01
Mitogen-activated protein kinase 1

4

20

Small-scale

0.893

High

290320

CDC37
Hsp90 co-chaperone Cdc37

3

13

High-throughput

0.871

High

290305

CSK2B
Casein kinase II subunit beta

3

9

High-throughput

0.855

High

290290

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.811

High

290291

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.811

High

290283

TNNC2
Troponin C, skeletal muscle

2

8

High-throughput

0.776

High

290288

KPCB
Protein kinase C beta type

2

17

High-throughput

0.737

High

158384

RFXK
DNA-binding protein RFXANK

1

3

High-throughput

0.691

High

290298

MK04
Mitogen-activated protein kinase 4

1

20

High-throughput

0.691

High

290310

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

9

High-throughput

0.691

High

290316

KS6A1
Ribosomal protein S6 kinase alpha-1

1

16

High-throughput

0.691

High

290317

IKBB
NF-kappa-B inhibitor beta

1

7

High-throughput

0.691

High

290318

MK11
Mitogen-activated protein kinase 11

1

20

High-throughput

0.691

High

290333

CDK20
Cyclin-dependent kinase 20

1

8

High-throughput

0.691

High

290360

NPTN
Neuroplastin

1

1

High-throughput

0.691

High

290296

MK03
Mitogen-activated protein kinase 3

1

20

Small-scale

0.665

High

167204

KLF11
Krueppel-like factor 11

1

5

High-throughput

0.665

High

290345

KLDC3
Kelch domain-containing protein 3

3

4

High-throughput

0.662

High

290309

SNTB2
Beta-2-syntrophin

1

17

High-throughput

0.618

High

290330

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

290350

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.618

High

290351

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

2

High-throughput

0.601

High

290353

ANLN
Anillin

1

0

High-throughput

0.586

High

231541

PRKY
Putative serine/threonine-protein kinase PRKY

1

16

High-throughput

0.575

High

290277

CIB2
Calcium and integrin-binding family member 2

1

16

High-throughput

0.575

High

290324

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

290325

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.575

High

290326

HS904
Putative heat shock protein HSP 90-alpha A4

1

20

High-throughput

0.575

High

290278

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.536

High

290279

DCTN3
Dynactin subunit 3

1

1

High-throughput

0.536

High

290285

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.536

High

290287

ANXA1
Annexin A1

1

5

High-throughput

0.536

High

290300

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.536

High

290301

OX2G
OX-2 membrane glycoprotein

1

2

High-throughput

0.536

High

290321

H2A2C
Histone H2A type 2-C

1

8

High-throughput

0.536

High

290322

MICA
MHC class I polypeptide-related sequence A

1

1

High-throughput

0.536

High

290327

H2A2A
Histone H2A type 2-A

1

8

High-throughput

0.536

High

290332

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

11

High-throughput

0.536

High

290338

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

290341

TCPQM
T-complex protein 1 subunit theta-like 2

1

17

High-throughput

0.536

High

290344

NPAS1
Neuronal PAS domain-containing protein 1

1

5

High-throughput

0.536

High

290358

CLC4A
C-type lectin domain family 4 member A

1

3

High-throughput

0.536

High

290292

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.515

High

261462

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

290281

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

290289

H10
Histone H1.0

1

0

High-throughput

0.513

High

290314

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

290340

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

290346

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

290349

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

290357

SCOC
Short coiled-coil protein

1

0

High-throughput

0.513

High

290282

FOS
Protein c-Fos

1

6

Small-scale

0.501

High

290293

CREB1
Cyclic AMP-responsive element-binding protein 1

1

5

Small-scale

0.501

High

290302

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

13

High-throughput

0.501

High

64334

CDHR4
Cadherin-related family member 4

1

2

High-throughput

0.489

High

290284

FETUA
Alpha-2-HS-glycoprotein

1

1

High-throughput

0.489

High

290334

KLH34
Kelch-like protein 34

1

6

High-throughput

0.489

High

290336

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

290347

DNAI2
Dynein axonemal intermediate chain 2

1

5

High-throughput

0.489

High

290359

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.489

High

290294

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

290295

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

290299

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

290303

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.479

High

290304

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

290307

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

290308

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

290311

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.479

High

290315

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.479

High

290323

WASC4
WASH complex subunit 4

1

2

High-throughput

0.479

High

290337

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

290339

SH3K1
SH3 domain-containing kinase-binding protein 1

1

10

High-throughput

0.479

High

290343

RING2
E3 ubiquitin-protein ligase RING2

1

6

High-throughput

0.479

High

290352

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

290354

AKA7G
A-kinase anchor protein 7 isoform gamma

1

5

High-throughput

0.479

High

290355

HECW2
E3 ubiquitin-protein ligase HECW2

1

13

High-throughput

0.479

High

290356

XPO7
Exportin-7

1

8

High-throughput

0.479

High

290306

E2F1
Transcription factor E2F1

1

3

High-throughput

0.445

High

290312

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.445

High

290313

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

290342

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.445

High

290328

GBP6
Guanylate-binding protein 6

1

3

High-throughput

0.437

High

290280

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.426

High

290329

PKHG7
Pleckstrin homology domain-containing family G member 7

1

9

High-throughput

0.407

High

290331

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

1

High-throughput

0.407

High

290286

SMR3B
Submaxillary gland androgen-regulated protein 3B

1

0

High-throughput

0.279

Low

290335

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025