HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: VPS21 (P36017)
Vacuolar protein sorting-associated protein 21 (GTP-binding protein YPT51) (Vacuolar protein-targeting protein 12)
Gene: VPS21

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	11805837, 37295430
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 210
+	Mm
		513667 HS90B_MOUSE (5-705): 0: 1025: 61.57		RAB1A_MOUSE (1-210): 2.74e-88: 260: 30.84
+	Mm
		432417 HS90A_MOUSE (4-705): 0: 1012: 60.59		RAB1A_MOUSE (1-210): 2.74e-88: 260: 30.84
+	Sc
		350841 HSC82_YEAST (1-705): 0: 977: 100.00		YPT1_YEAST (2-209): 3.58e-85: 252: 31.73
+	Sc
		350829 HSP82_YEAST (1-705): 0: 968: 95.63		YPT1_YEAST (2-209): 3.58e-85: 252: 31.73
+	Sc
		366107 HSP82_YEAST (1-705): 0: 968: 95.63		YPT53_YEAST (7-210): 8.68e-75: 226: 56.94
+	Mm
		432412 HS90A_MOUSE (4-705): 0: 1012: 60.59		RAB21_MOUSE (7-210): 5.99e-44: 147: 39.02
+	Mm
		432413 HS90A_MOUSE (4-705): 0: 1012: 60.59		RAB17_MOUSE (9-188): 1.57e-43: 146: 41.99
+	Sc
		543536 HSC82_YEAST (1-705): 0: 977: 100.00		YPT52_YEAST (9-208): 5.36e-57: 181: 48.25
+	Sc
		366106 HSP82_YEAST (1-705): 0: 968: 95.63		YPT52_YEAST (9-208): 5.36e-57: 181: 48.25
+	Mm
		435916 ENPL_MOUSE (3-705): 0: 897: 46.03		RAB5C_MOUSE (5-209): 8.55e-64: 198: 54.15
+	Dm
		1358711 Q9VAY2_DROME (3-676): 0: 833: 47.09		RAB5_DROME (9-172): 1.51e-64: 200: 64.63
+	Dm
		185627 Q9VAY2_DROME (3-676): 0: 833: 47.09		RAB6_DROME (9-210): 1.28e-44: 149: 38.92