HitPredict

Interactor 1: PTC (P18502)
Protein patched (Hedgehog receptor)
Gene: PTC

Interactor 2: Q9VXR3 (Q9VXR3)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
Gene: HUWE1

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.439

Property	Details
Experiments	15710747
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1286 Dm			1 5146
+	Dm
		577405 PTC_DROME (1-1286): 0: 1295: 100.00		NEDD4_DROME (4290-5143): 0: 676: 23.51
+	Dm
		577424 PTC_DROME (1-1286): 0: 1295: 100.00		SUDX_DROME (4527-5143): 0: 650: 29.79
+	Hs
		1044434 PTC1_HUMAN (24-1261): 0: 1165: 37.25		WWP1_HUMAN (4308-5144): 0: 737: 25.03
+	Dm
		577378 PTC_DROME (1-1286): 0: 1295: 100.00		SMUF1_DROME (4207-5143): 2.92e-177: 580: 23.43
+	Hs
		1044412 PTC1_HUMAN (24-1261): 0: 1165: 37.25		ITCH_HUMAN (4383-5144): 0: 701: 24.81
+	Hs
		125442 PTC1_HUMAN (24-1261): 0: 1165: 37.25		WWP2_HUMAN (4252-5144): 0: 694: 23.03
+	Hs
		1044417 PTC1_HUMAN (24-1261): 0: 1165: 37.25		NED4L_HUMAN (4371-5144): 0: 683: 26.12
+	Hs
		808120 PTC1_HUMAN (24-1261): 0: 1165: 37.25		NEDD4_HUMAN (3950-5144): 0: 656: 21.37
+	Hs
		1044440 PTC1_HUMAN (24-1261): 0: 1165: 37.25		SMUF2_HUMAN (4547-5143): 0: 630: 29.71
+	Hs
		1044442 PTC1_HUMAN (24-1261): 0: 1165: 37.25		SMUF1_HUMAN (4587-5143): 0: 610: 30.12
+	Hs
		168027 NPC1_HUMAN (59-1111): 0: 736: 18.69		WWP1_HUMAN (4308-5144): 0: 737: 25.03
+	Hs
		168007 NPC1_HUMAN (59-1111): 0: 736: 18.69		NED4L_HUMAN (4371-5144): 0: 683: 26.12
+	Hs
		167863 NPC1_HUMAN (59-1111): 0: 736: 18.69		NEDD4_HUMAN (3950-5144): 0: 656: 21.37