HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: M3K11 (Q16584)
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)
Gene: MAP3K11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 847
+	Hs
		988397 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		M3K11_HUMAN (1-847): 0: 662: 100.00
+	Hs
		953471 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		M3K11_HUMAN (1-847): 0: 662: 100.00
+	Hs
		1015466 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		M3K11_HUMAN (1-847): 0: 662: 100.00
+	Hs
		955218 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		M3K11_HUMAN (1-847): 0: 662: 100.00
+	Hs
		988297 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		M3K10_HUMAN (38-841): 4.8e-162: 498: 44.11
+	Hs
		955075 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		M3K10_HUMAN (38-841): 4.8e-162: 498: 44.11
+	Hs
		953498 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		M3K21_HUMAN (45-830): 3.07e-150: 469: 46.42
+	Dm
		828010 RAC1_DROME (1-192): 1.49e-83: 246: 89.06		M3KSL_DROME (43-648): 1.51e-126: 410: 42.77
+	Dm
		828049 CDC42_DROME (1-192): 4.13e-78: 233: 69.27		M3KSL_DROME (43-648): 1.51e-126: 410: 42.77
+	Dm
		870517 RHO1_DROME (5-192): 5.39e-75: 225: 55.85		M3KSL_DROME (43-648): 1.51e-126: 410: 42.77
+	Hs
		212016 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		M3K13_HUMAN (85-781): 7.57e-121: 390: 26.60
+	Hs
		955677 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		M3K20_HUMAN (108-847): 2.43e-122: 390: 21.30
+	Hs
		955093 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		ACK1_HUMAN (62-847): 3.05e-116: 379: 22.06
+	Dm
		92264 RHO1_DROME (5-192): 5.39e-75: 225: 55.85		D3DMF6_DROME (110-683): 5.74e-120: 387: 27.00
+	Rn
		1216897 CDC42_RAT (1-192): 1.66e-78: 234: 68.75		ACK1_RAT (62-847): 5.14e-113: 371: 21.76
+	Hs
		841004 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		FRK_HUMAN (113-377): 1.14e-100: 323: 34.06