HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: M3K11 (Q16584)
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)
Gene: MAP3K11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.874

Property	Details
Experiments	9427749, 10799501, 31871319, 20890305
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 847
+	Hs
		988397 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		M3K11_HUMAN (1-847): 0: 662: 100.00
+	Hs
		1015466 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		M3K11_HUMAN (1-847): 0: 662: 100.00
+	Hs
		581073 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		M3K11_HUMAN (1-847): 0: 662: 100.00
+	Hs
		953471 RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32		M3K11_HUMAN (1-847): 0: 662: 100.00
+	Hs
		988297 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		M3K10_HUMAN (38-841): 4.8e-162: 498: 44.11
+	Hs
		955075 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		M3K10_HUMAN (38-841): 4.8e-162: 498: 44.11
+	Hs
		953498 RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32		M3K21_HUMAN (45-830): 3.07e-150: 469: 46.42
+	Dm
		828010 RAC1_DROME (1-191): 3.87e-79: 235: 69.27		M3KSL_DROME (43-648): 1.51e-126: 410: 42.77
+	Dm
		828049 CDC42_DROME (1-191): 2.27e-78: 233: 92.67		M3KSL_DROME (43-648): 1.51e-126: 410: 42.77
+	Dm
		870517 RHO1_DROME (5-191): 1.09e-74: 224: 54.55		M3KSL_DROME (43-648): 1.51e-126: 410: 42.77
+	Hs
		212016 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		M3K13_HUMAN (85-781): 7.57e-121: 390: 26.60
+	Hs
		955677 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		M3K20_HUMAN (108-847): 2.43e-122: 390: 21.30
+	Hs
		955093 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		ACK1_HUMAN (62-847): 3.05e-116: 379: 22.06
+	Dm
		92264 RHO1_DROME (5-191): 1.09e-74: 224: 54.55		D3DMF6_DROME (110-683): 5.74e-120: 387: 27.00
+	Rn
		1216897 CDC42_RAT (1-191): 9.95e-80: 237: 100.00		ACK1_RAT (62-847): 5.14e-113: 371: 21.76
+	Hs
		841004 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		FRK_HUMAN (113-377): 1.14e-100: 323: 34.06