HitPredict

Interactor 1: UBC4 (P15731)
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)
Gene: UBC4

Interactor 2: UBA1 (P22515)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)
Gene: UBA1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	17632060, 9341106, 22072716, 22085930
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 148 Sc			1 1024
+	Hs
		647684 UB2D4_HUMAN (2-148): 1.6e-83: 243: 79.59		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647506 UB2D1_HUMAN (2-148): 8.05e-83: 241: 78.23		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647533 UB2D2_HUMAN (2-148): 1.47e-82: 240: 78.91		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647521 UB2D3_HUMAN (2-148): 2.21e-81: 238: 78.91		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647626 UB2E2_HUMAN (2-147): 5.74e-76: 226: 64.38		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647619 UB2E3_HUMAN (2-147): 1.44e-75: 225: 64.38		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647508 UB2E1_HUMAN (2-147): 5.63e-74: 220: 64.38		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647502 UBE2A_HUMAN (3-145): 9.45e-71: 211: 37.06		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647524 UBE2N_HUMAN (4-148): 5.96e-70: 209: 46.90		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Hs
		647537 UBE2B_HUMAN (3-145): 5.58e-70: 209: 37.06		UBA1_HUMAN (2-1023): 0: 1129: 51.55
+	Sp
		314596 UBC4_SCHPO (2-148): 7.54e-81: 236: 82.31		UBA1_SCHPO (1-1024): 0: 1045: 58.19
+	Sp
		150903 UBC13_SCHPO (1-148): 2.78e-71: 212: 50.00		UBA1_SCHPO (1-1024): 0: 1045: 58.19
+	Dm
		762720 UBE2N_DROME (1-148): 1.31e-69: 208: 48.32		Q8T0L3_DROME (2-1024): 0: 1020: 49.08
+	Hs
		48347 UB2D1_HUMAN (2-148): 8.05e-83: 241: 78.23		UBA6_HUMAN (2-1024): 0: 974: 40.71
+	Hs
		48351 UB2D2_HUMAN (2-148): 1.47e-82: 240: 78.91		UBA6_HUMAN (2-1024): 0: 974: 40.71
+	Hs
		48349 UB2D3_HUMAN (2-148): 2.21e-81: 238: 78.91		UBA6_HUMAN (2-1024): 0: 974: 40.71
+	Sp
		268150 UBC1_SCHPO (4-147): 3.37e-44: 145: 46.21		UBA1_SCHPO (1-1024): 0: 1045: 58.19
+	Hs
		833587 UB2E1_HUMAN (2-147): 5.63e-74: 220: 64.38		UBA7_HUMAN (5-1024): 0: 913: 37.09
+	Hs
		1381215 UB2E3_HUMAN (2-147): 1.44e-75: 225: 64.38		SAE2_HUMAN (24-440): 1.02e-74: 261: 16.14
+	Hs
		982256 UB2D2_HUMAN (2-148): 1.47e-82: 240: 78.91		UBA3_HUMAN (790-994): 6.5e-41: 159: 14.55