Protein: UBA6
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)

Gene: UBA6
Organism: Homo sapiens
Interactions: 89
UniProt ID: A0AVT1

Gene Ontology (top 5):
GO:0004839 - ubiquitin activating enzyme activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

48386

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

11

20

Small-scale

0.976

High

48351

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

19

Small-scale

0.942

High

48331

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

15

Small-scale

0.899

High

48352

UB2L3
Ubiquitin-conjugating enzyme E2 L3

4

20

Small-scale

0.888

High

48320

UBD
Ubiquitin D

3

16

Small-scale

0.849

High

48390

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

2

20

Small-scale

0.806

High

48318

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

2

20

Small-scale

0.799

High

48347

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

48348

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

Small-scale

0.647

High

48349

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

48358

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

20

Small-scale

0.647

High

48387

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

20

Small-scale

0.647

High

48382

UIF
UAP56-interacting factor

3

0

High-throughput

0.638

High

48344

RHG25
Rho GTPase-activating protein 25

3

3

High-throughput

0.609

High

48345

AL3B1
Aldehyde dehydrogenase family 3 member B1

2

0

High-throughput

0.602

High

48359

PKHO1
Pleckstrin homology domain-containing family O member 1

2

0

High-throughput

0.602

High

48372

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

48403

CAN6
Calpain-6

2

0

High-throughput

0.602

High

48363

HMBX1
Homeobox-containing protein 1

1

3

High-throughput

0.573

High

48336

RBTN2
Rhombotin-2

1

0

Small-scale

0.549

High

48339

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

48342

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.536

High

48346

FXR1
RNA-binding protein FXR1

1

2

High-throughput

0.536

High

48353

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.536

High

48369

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.536

High

48373

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

1

High-throughput

0.536

High

48380

FA81B
Protein FAM81B

1

1

High-throughput

0.536

High

48388

ANLN
Anillin

1

1

High-throughput

0.536

High

48401

SAR1B
Small COPII coat GTPase SAR1B

1

4

High-throughput

0.536

High

48338

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

48399

KIF3A
Kinesin-like protein KIF3A

1

0

High-throughput

0.513

High

48319

SMAD9
Mothers against decapentaplegic homolog 9

1

2

High-throughput

0.508

High

48333

JUNB
Transcription factor JunB

1

4

Small-scale

0.501

High

48365

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

Small-scale

0.501

High

48377

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.501

High

48360

ANR39
Ankyrin repeat domain-containing protein 39

1

4

High-throughput

0.489

High

48398

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

48316

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

48321

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

48322

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

48327

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

48328

LDHA
L-lactate dehydrogenase A chain

1

1

High-throughput

0.479

High

48330

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

48332

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

48337

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

48343

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

48355

SMAD4
Mothers against decapentaplegic homolog 4

1

2

High-throughput

0.479

High

48356

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

48357

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

48364

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

48366

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

4

Small-scale

0.479

High

48374

TOPB1
DNA topoisomerase 2-binding protein 1

1

3

High-throughput

0.479

High

48378

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

5

High-throughput

0.479

High

48381

KI20B
Kinesin-like protein KIF20B

1

1

High-throughput

0.479

High

48385

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

48391

HELLS
Lymphoid-specific helicase

1

3

Small-scale

0.479

High

48393

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

48394

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

1

3

Small-scale

0.479

High

48395

MBD5
Methyl-CpG-binding domain protein 5

1

1

High-throughput

0.479

High

48396

HERC5
E3 ISG15--protein ligase HERC5

1

11

Small-scale

0.479

High

48326

VATG2
V-type proton ATPase subunit G 2

1

0

High-throughput

0.458

High

48341

SPB5
Serpin B5

1

0

High-throughput

0.458

High

48370

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

48317

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.445

High

48362

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

48367

DND1
Dead end protein homolog 1

1

2

High-throughput

0.445

High

48384

PCGF6
Polycomb group RING finger protein 6

1

3

High-throughput

0.445

High

48389

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

48392

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

48397

GAB2
GRB2-associated-binding protein 2

1

3

High-throughput

0.445

High

48315

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

48335

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

48340

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

48329

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

48350

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

0

High-throughput

0.426

High

48375

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

48325

VENTX
Homeobox protein VENTX

1

7

High-throughput

0.407

High

48334

CAP7
Azurocidin

1

3

High-throughput

0.407

High

48354

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

48368

TTC9C
Tetratricopeptide repeat protein 9C

1

5

High-throughput

0.407

High

48379

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.407

High

48400

PCDG9
Protocadherin gamma-A9

1

1

High-throughput

0.407

High

48324

OR5F1
Olfactory receptor 5F1

3

0

High-throughput

0.347

High

48383

CD006
Uncharacterized protein encoded by LINC01587

2

0

High-throughput

0.318

High

48361

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

48371

RAB2B
Ras-related protein Rab-2B

1

0

High-throughput

0.279

Low

48376

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.279

Low

48402

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

48323

RTN3
Reticulon-3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025