HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33961781, 23211419
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Hs			1 949
+	Hs
		833572 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Rn
		923852 Q3MUI1_RAT (1-651): 2.15e-78: 262: 83.13		AP2B1_RAT (1-949): 0: 944: 81.45
+	Hs
		1014028 ARH_HUMAN (4-293): 1.38e-52: 185: 19.67		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		925893 ARH_HUMAN (4-293): 1.38e-52: 185: 19.67		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		926067 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		925962 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		253551 CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		321513 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Ce
		283753 CED6_CAEEL (7-402): 5.6e-36: 143: 14.85		Q9N4F3_CAEEL (1-947): 0: 819: 63.06
+	Hs
		302120 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Rn
		577194 Q3MUI1_RAT (1-651): 2.15e-78: 262: 83.13		AP2A2_RAT (12-945): 0: 635: 17.94
+	Rn
		1109842 Q3MUI1_RAT (1-651): 2.15e-78: 262: 83.13		Q66HM2_RAT (12-945): 0: 631: 17.92
+	Mm
		567529 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		AP2A2_MOUSE (12-945): 0: 634: 17.94
+	Hs
		321528 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Dm
		561275 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		AP2A_DROME (12-943): 0: 608: 16.06
+	Hs
		302137 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Dm
		561280 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		Q7KVR8_DROME (12-822): 3.54e-159: 495: 14.02
+	Ce
		60777 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q8WQB3_CAEEL (14-823): 3.78e-159: 490: 13.65
+	Ce
		60774 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q22601_CAEEL (14-746): 1.07e-157: 489: 18.58
+	Ce
		283751 CED6_CAEEL (7-402): 5.6e-36: 143: 14.85		Q22601_CAEEL (14-746): 1.07e-157: 489: 18.58