HitPredict

Interactor 1: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Interactor 2: DUS3 (P51452)
Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)
Gene: DUSP3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	10224087, 12840032
Identification Methods	enzymatic study, affinity chromatography technology, phosphatase assay
Interaction Type	direct interaction, physical association, dephosphorylation reaction

Property	Details
Interacting Pfam domains	DSPc~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 379 Hs			1 185
+	Hs
		658858 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		DUS3_HUMAN (1-185): 4.89e-72: 217: 100.00
+	Hs
		647475 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS1_HUMAN (1-184): 1.58e-59: 191: 25.36
+	Mm
		926438 MK01_MOUSE (28-374): 6.16e-154: 439: 87.61		DUS3_MOUSE (1-184): 8.03e-69: 208: 93.48
+	Hs
		647563 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS4_HUMAN (1-184): 5.9e-59: 190: 25.84
+	Hs
		647595 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS5_HUMAN (1-181): 4.22e-58: 188: 25.60
+	Hs
		647672 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS26_HUMAN (7-178): 2.94e-60: 188: 41.86
+	Hs
		647564 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS8_HUMAN (1-184): 7.72e-55: 185: 26.15
+	Hs
		647553 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS2_HUMAN (1-178): 1.63e-57: 184: 29.23
+	Hs
		647598 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS7_HUMAN (17-181): 6.25e-56: 183: 32.53
+	Hs
		647665 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS9_HUMAN (14-182): 1.93e-55: 181: 31.61
+	Hs
		647597 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DUS6_HUMAN (17-181): 9.01e-55: 179: 31.33
+	Hs
		658798 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		DUS1_HUMAN (1-184): 1.58e-59: 191: 25.36
+	Hs
		658919 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		DUS4_HUMAN (1-184): 5.9e-59: 190: 25.84
+	Hs
		658960 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		DUS5_HUMAN (1-181): 4.22e-58: 188: 25.60
+	Rn
		600398 MK03_RAT (13-379): 1.37e-155: 444: 97.55		Q2YDV1_RAT (14-178): 4.08e-55: 181: 31.77
+	Hs
		658923 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		DUS8_HUMAN (1-184): 7.72e-55: 185: 26.15
+	Hs
		658903 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		DUS2_HUMAN (1-178): 1.63e-57: 184: 29.23
+	Mm
		926403 MK01_MOUSE (28-374): 6.16e-154: 439: 87.61		DUS2_MOUSE (1-178): 6.29e-56: 180: 29.23
+	Mm
		926439 MK01_MOUSE (28-374): 6.16e-154: 439: 87.61		DUS6_MOUSE (17-181): 1.35e-54: 178: 31.33
+	Rn
		926496 MK01_RAT (28-374): 6.16e-154: 439: 87.61		DUS6_RAT (17-181): 1.35e-54: 178: 31.33