HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UBE2A (P49459)
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Gene: UBE2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.959

Property	Details
Experiments	25527291, 27425610, 31887036, 36563856, 37558718, 22427669, 17597759
Identification Methods	enzymatic study, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1058 Hs			1 152
+	Hs
		647684 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (5-149): 3.34e-79: 232: 40.69
+	Hs
		647506 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (5-149): 1.64e-78: 230: 40.00
+	Hs
		647533 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (5-149): 2.43e-78: 230: 38.62
+	Hs
		647521 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (5-149): 5.84e-77: 226: 38.62
+	Hs
		647537 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (1-151): 2.1e-74: 220: 96.03
+	Hs
		647626 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (3-150): 3.02e-73: 219: 35.14
+	Hs
		647619 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (3-150): 9.62e-73: 218: 35.14
+	Hs
		647508 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (3-150): 2.46e-71: 214: 36.49
+	Sp
		314596 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (5-149): 4.84e-77: 226: 38.62
+	Sc
		585681 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (1-149): 6.31e-78: 229: 36.91
+	Sp
		314595 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (1-150): 1.25e-70: 211: 72.00
+	Sc
		438521 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC2_YEAST (1-150): 2.38e-73: 218: 69.33
+	Hs
		48347 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (5-149): 1.64e-78: 230: 40.00
+	Hs
		48351 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (5-149): 2.43e-78: 230: 38.62
+	Hs
		48349 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (5-149): 5.84e-77: 226: 38.62
+	Hs
		833587 UBA7_HUMAN (41-1057): 0: 1006: 46.00		UB2E1_HUMAN (3-150): 2.46e-71: 214: 36.49
+	Sp
		122416 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC7_SCHPO (5-148): 1.49e-37: 127: 39.87
+	Hs
		1381215 SAE2_HUMAN (60-451): 2.58e-88: 299: 17.08		UB2E3_HUMAN (3-150): 9.62e-73: 218: 35.14
+	Hs
		982256 UBA3_HUMAN (847-1018): 1.75e-12: 72.9: 17.13		UB2D2_HUMAN (5-149): 2.43e-78: 230: 38.62