HitPredict

Interactor 1: CCND1 (P24385)
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene: CCND1

Interactor 2: RBL2 (Q08999)
Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)
Gene: RBL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	16600870
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 295 Hs			1 1139
+	Hs
		943777 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		538529 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		590169 CCNA2_HUMAN (3-286): 6.9e-81: 252: 24.48		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		673066 CCND2_HUMAN (3-295): 5.15e-81: 248: 61.22		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		673145 CCND3_HUMAN (3-295): 2.73e-76: 236: 51.69		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		331639 CCNE2_HUMAN (44-188): 8.58e-19: 87.4: 32.65		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		624579 CCNE1_HUMAN (25-208): 7.3e-18: 84.7: 28.50		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		660112 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		590128 CCNA2_HUMAN (3-286): 6.9e-81: 252: 24.48		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		624544 CCNE1_HUMAN (25-208): 7.3e-18: 84.7: 28.50		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		414240 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414150 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Mm
		527133 CCND3_MOUSE (4-295): 5.1e-86: 261: 50.51		RB_MOUSE (762-1032): 6.63e-68: 248: 27.24
+	Mm
		527131 CCND1_MOUSE (1-295): 1.76e-82: 252: 93.90		RB_MOUSE (762-1032): 6.63e-68: 248: 27.24
+	Hs
		414164 CCNA2_HUMAN (3-286): 6.9e-81: 252: 24.48		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414187 CCND2_HUMAN (3-295): 5.15e-81: 248: 61.22		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414188 CCND3_HUMAN (3-295): 2.73e-76: 236: 51.69		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414169 CCND1_HUMAN (1-295): 1.33e-74: 232: 100.00		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	At
		1228116 CCD41_ARATH (24-214): 5.3e-18: 84.3: 32.16		RBR1_ARATH (819-1112): 2.17e-75: 272: 23.72
+	Hs
		414171 CCNE1_HUMAN (25-208): 7.3e-18: 84.7: 28.50		RB_HUMAN (775-999): 1.19e-64: 239: 29.39